A Chromatin-associated Kinesin-related Protein Required for Normal Mitotic Chromosome Segregation in Drosophila

The tiovivo (tio) gene of Drosophila encodes a kinesin-related protein, KLP38B, that colocalizes with condensed chromatin during cell division. Wild-type function of the tio gene product KLP38B is required for normal chromosome segregation during mitosis. Mitotic cells in tio larval brains displayed...

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Autores principales: Molina, Isabel, Baars, Sigrid, Brill, Julie A., Hales, Karen G., Fuller, Margaret T., Ripoll, Pedro
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1997
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132616/
https://www.ncbi.nlm.nih.gov/pubmed/9396743
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author Molina, Isabel
Baars, Sigrid
Brill, Julie A.
Hales, Karen G.
Fuller, Margaret T.
Ripoll, Pedro
author_facet Molina, Isabel
Baars, Sigrid
Brill, Julie A.
Hales, Karen G.
Fuller, Margaret T.
Ripoll, Pedro
author_sort Molina, Isabel
collection PubMed
description The tiovivo (tio) gene of Drosophila encodes a kinesin-related protein, KLP38B, that colocalizes with condensed chromatin during cell division. Wild-type function of the tio gene product KLP38B is required for normal chromosome segregation during mitosis. Mitotic cells in tio larval brains displayed circular mitotic figures, increased ploidy, and abnormal anaphase figures. KLP38B mRNA is maternally provided and expressed in cells about to undergo division. We propose that KLP38B, perhaps redundantly with other chromosome-associated microtubule motor proteins, contributes to interactions between chromosome arms and microtubules important for establishing bipolar attachment of chromosomes and assembly of stable bipolar spindles.
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spelling pubmed-21326162008-05-01 A Chromatin-associated Kinesin-related Protein Required for Normal Mitotic Chromosome Segregation in Drosophila Molina, Isabel Baars, Sigrid Brill, Julie A. Hales, Karen G. Fuller, Margaret T. Ripoll, Pedro J Cell Biol Article The tiovivo (tio) gene of Drosophila encodes a kinesin-related protein, KLP38B, that colocalizes with condensed chromatin during cell division. Wild-type function of the tio gene product KLP38B is required for normal chromosome segregation during mitosis. Mitotic cells in tio larval brains displayed circular mitotic figures, increased ploidy, and abnormal anaphase figures. KLP38B mRNA is maternally provided and expressed in cells about to undergo division. We propose that KLP38B, perhaps redundantly with other chromosome-associated microtubule motor proteins, contributes to interactions between chromosome arms and microtubules important for establishing bipolar attachment of chromosomes and assembly of stable bipolar spindles. The Rockefeller University Press 1997-12-15 /pmc/articles/PMC2132616/ /pubmed/9396743 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Molina, Isabel
Baars, Sigrid
Brill, Julie A.
Hales, Karen G.
Fuller, Margaret T.
Ripoll, Pedro
A Chromatin-associated Kinesin-related Protein Required for Normal Mitotic Chromosome Segregation in Drosophila
title A Chromatin-associated Kinesin-related Protein Required for Normal Mitotic Chromosome Segregation in Drosophila
title_full A Chromatin-associated Kinesin-related Protein Required for Normal Mitotic Chromosome Segregation in Drosophila
title_fullStr A Chromatin-associated Kinesin-related Protein Required for Normal Mitotic Chromosome Segregation in Drosophila
title_full_unstemmed A Chromatin-associated Kinesin-related Protein Required for Normal Mitotic Chromosome Segregation in Drosophila
title_short A Chromatin-associated Kinesin-related Protein Required for Normal Mitotic Chromosome Segregation in Drosophila
title_sort chromatin-associated kinesin-related protein required for normal mitotic chromosome segregation in drosophila
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132616/
https://www.ncbi.nlm.nih.gov/pubmed/9396743
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