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The Pathway of Membrane Fusion Catalyzed by Influenza Hemagglutinin: Restriction of Lipids, Hemifusion, and Lipidic Fusion Pore Formation

The mechanism of bilayer unification in biological fusion is unclear. We reversibly arrested hemagglutinin (HA)-mediated cell–cell fusion right before fusion pore opening. A low-pH conformation of HA was required to form this intermediate and to ensure fusion beyond it. We present evidence indicatin...

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Detalles Bibliográficos
Autores principales: Chernomordik, Leonid V., Frolov, Vadim A., Leikina, Eugenia, Bronk, Peter, Zimmerberg, Joshua
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1998
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132678/
https://www.ncbi.nlm.nih.gov/pubmed/9508770