Cargando…

Detection of a Novel Intraneuronal Pool of Insoluble Amyloid β Protein that Accumulates with Time in Culture

The amyloid-β peptide (Aβ) is produced at several sites within cultured human NT2N neurons with Aβ1-42 specifically generated in the endoplasmic reticulum/intermediate compartment. Since Aβ is found as insoluble deposits in senile plaques of the AD brain, and the Aβ peptide can polymerize into insol...

Descripción completa

Detalles Bibliográficos
Autores principales:	Skovronsky, Daniel M., Doms, Robert W., Lee, Virginia M.-Y.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 1998
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132781/ https://www.ncbi.nlm.nih.gov/pubmed/9585420

Ejemplares similares

A Bifunctional Anti-Amyloid Blocks Oxidative Stress and the Accumulation of Intraneuronal Amyloid-Beta
por: Hilt, Silvia, et al.
Publicado: (2018)

Senescence-related impairment of autophagy induces toxic intraneuronal amyloid-β accumulation in a mouse model of amyloid pathology
por: Suelves, Nuria, et al.
Publicado: (2023)

Intraneuronal β-Amyloid Accumulation: Aging HIV-1 Human and HIV-1 Transgenic Rat Brain
por: Li, Hailong, et al.
Publicado: (2022)

Accumulation of intraneuronal Aβ correlates with ApoE4 genotype
por: Christensen, Ditte Z., et al.
Publicado: (2010)

Accumulation of Intraneuronal β-Amyloid 42 Peptides Is Associated with Early Changes in Microtubule-Associated Protein 2 in Neurites and Synapses
por: Takahashi, Reisuke H., et al.
Publicado: (2013)

Age-Related Intraneuronal Aggregation of Amyloid-β in Endosomes, Mitochondria, Autophagosomes, and Lysosomes
por: Brewer, Gregory J., et al.
Publicado: (2020)

Intraneuronal accumulation of amyloid-β peptides as the pathomechanism linking autism and its co-morbidities: epilepsy and self-injurious behavior — the hypothesis
por: Frackowiak, Janusz, et al.
Publicado: (2023)

Herpes Simplex Virus type-1 infection induces synaptic dysfunction in cultured cortical neurons via GSK-3 activation and intraneuronal amyloid-β protein accumulation
por: Piacentini, Roberto, et al.
Publicado: (2015)

Lysosomal dysfunction in the brain of a mouse model with intraneuronal accumulation of carboxyl terminal fragments of the amyloid precursor protein
por: Kaur, Gurjinder, et al.
Publicado: (2016)

Vulnerability of primary neurons derived from Tg2576 Alzheimer mice to oxygen and glucose deprivation: role of intraneuronal amyloid-β accumulation and astrocytes
por: Baldassarro, Vito Antonio, et al.
Publicado: (2017)

Age-Related Oxidative Redox and Metabolic Changes Precede Intraneuronal Amyloid-β Accumulation and Plaque Deposition in a Transgenic Alzheimer’s Disease Mouse Model
por: Pontrello, Crystal G., et al.
Publicado: (2022)

ApoE4-Driven Accumulation of Intraneuronal Oligomerized Aβ42 following Activation of the Amyloid Cascade In Vivo Is Mediated by a Gain of Function
por: Zepa, Lia, et al.
Publicado: (2011)

The ability of apolipoprotein E fragments to promote intraneuronal accumulation of amyloid beta peptide 42 is both isoform and size-specific
por: Dafnis, Ioannis, et al.
Publicado: (2016)

New Alzheimer’s disease model mouse specialized for analyzing the function and toxicity of intraneuronal Amyloid β oligomers
por: Ochiishi, Tomoyo, et al.
Publicado: (2019)

Synapses, Synaptic Activity and Intraneuronal Aβ in Alzheimer's Disease
por: Tampellini, Davide, et al.
Publicado: (2010)

Modeling of age-dependent amyloid accumulation and γ-secretase inhibition of soluble and insoluble Aβ in a transgenic mouse model of amyloid deposition
por: Parkinson, Joanna, et al.
Publicado: (2013)

Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody
por: Youmans, Katherine L, et al.
Publicado: (2012)

Amyloid β accelerates age-related proteome-wide protein insolubility.
por: Anderton, Edward, et al.
Publicado: (2023)

Axonal degeneration in an Alzheimer mouse model is PS1 gene dose dependent and linked to intraneuronal Aβ accumulation
por: Christensen, Ditte Z., et al.
Publicado: (2014)

Synaptophysin depletion and intraneuronal Aβ in organotypic hippocampal slice cultures from huAPP transgenic mice
por: Harwell, Claire S., et al.
Publicado: (2016)

Intraneuronal Aβ immunoreactivity is not a predictor of brain amyloidosis-β or neurofibrillary degeneration
por: Wegiel, Jerzy, et al.
Publicado: (2007)

Novel β-Secretase Cleavage of β-Amyloid Precursor Protein in the Endoplasmic Reticulum/Intermediate Compartment of NT2N Cells
por: Chyung, Abraham S.C., et al.
Publicado: (1997)

Early intraneuronal amyloid triggers neuron-derived inflammatory signaling in APP transgenic rats and human brain
por: Welikovitch, Lindsay A., et al.
Publicado: (2020)

Neuron loss in the 5XFAD mouse model of Alzheimer’s disease correlates with intraneuronal Aβ(42) accumulation and Caspase-3 activation
por: Eimer, William A, et al.
Publicado: (2013)

Selective Aptamer‐Based Control of Intraneuronal Signaling
por: Lennarz, Sabine, et al.
Publicado: (2015)

Dopamine induces the accumulation of insoluble prion protein and affects autophagic flux
por: da Luz, Marcio H. M., et al.
Publicado: (2015)

Intraneuronal tau aggregation induces the integrated stress response in astrocytes
por: Batenburg, Kevin L, et al.
Publicado: (2022)

Chemogenetic emulation of intraneuronal oxidative stress affects synaptic plasticity
por: Kalinichenko, Andrei L., et al.
Publicado: (2023)

Arrestin-mediated desensitization enables intraneuronal olfactory discrimination in Caenorhabditis elegans
por: Merritt, Daniel M., et al.
Publicado: (2022)

The link between intraneuronal N-truncated amyloid-β peptide and oxidatively modified lipids in idiopathic autism and dup(15q11.2-q13)/autism
por: Frackowiak, Janusz, et al.
Publicado: (2013)

Intraneuronal aggregation of the β-CTF fragment of APP (C99) induces Aβ-independent lysosomal-autophagic pathology
por: Lauritzen, Inger, et al.
Publicado: (2016)

Increased Insoluble Amyloid-β Induces Negligible Cognitive Deficits in Old App(NL/NL) Knock-In Mice
por: Salas, Isabel H., et al.
Publicado: (2018)

Derailed Intraneuronal Signalling Drives Pathogenesis in Sporadic and Familial Alzheimer's Disease
por: Van Dooren, Tom, et al.
Publicado: (2014)

Intraneuronal APP and extracellular Aβ independently cause dendritic spine pathology in transgenic mouse models of Alzheimer’s disease
por: Zou, Chengyu, et al.
Publicado: (2015)

Amyloid-Beta 1-42 Cross-Reactive Antibody Prevalent in Human Sera May Contribute to Intraneuronal Deposition of A-Beta-P-42
por: Vojdani, Aristo, et al.
Publicado: (2018)

Detection of Soluble Amyloid-β Oligomers and Insoluble High-Molecular-Weight Particles in CSF: Development of Methods with Potential for Diagnosis and Therapy Monitoring of Alzheimer's Disease
por: Funke, Susanne Aileen
Publicado: (2011)

SUMO-2 and PIAS1 Modulate Insoluble Mutant Huntingtin Protein Accumulation
por: O’Rourke, Jacqueline Gire, et al.
Publicado: (2013)

Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer’s disease
por: Sosna, Justyna, et al.
Publicado: (2018)

N-truncated Abeta starting with position four: early intraneuronal accumulation and rescue of toxicity using NT4X-167, a novel monoclonal antibody
por: Antonios, Gregory, et al.
Publicado: (2013)

The Transcription Factor EB Reduces the Intraneuronal Accumulation of the Beta-Secretase-Derived APP Fragment C99 in Cellular and Mouse Alzheimer’s Disease Models
por: Bécot, Anaïs, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_rbom2r4p1gaksnm8ripfksncqk