Disruption of the NF-H Gene Increases Axonal Microtubule Content and Velocity of Neurofilament Transport: Relief of Axonopathy Resulting from the Toxin β,β′-Iminodipropionitrile

To investigate the role of the neurofilament heavy (NF-H) subunit in neuronal function, we generated mice bearing a targeted disruption of the gene coding for the NF-H subunit. Surprisingly, the lack of NF-H subunits had little effect on axonal calibers and electron microscopy revealed no significan...

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Detalles Bibliográficos
Autores principales: Zhu, Qinzhang, Lindenbaum, Michael, Levavasseur, Françoise, Jacomy, Hélène, Julien, Jean-Pierre
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1998
Materias:
Regular Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132812/
https://www.ncbi.nlm.nih.gov/pubmed/9763430

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132812/
https://www.ncbi.nlm.nih.gov/pubmed/9763430

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