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Removal of the Membrane-anchoring Domain of Epidermal Growth Factor Leads to Intracrine Signaling and Disruption of Mammary Epithelial Cell Organization
Autocrine EGF-receptor (EGFR) ligands are normally made as membrane-anchored precursors that are proteolytically processed to yield mature, soluble peptides. To explore the function of the membrane-anchoring domain of EGF, we expressed artificial EGF genes either with or without this structure in hu...
Autores principales: | Wiley, H. Steven, Woolf, Margaret F., Opresko, Lee K., Burke, Patrick M., Will, Birgit, Morgan, Jeffrey R., Lauffenburger, Douglas A. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
1998
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2133076/ https://www.ncbi.nlm.nih.gov/pubmed/9832559 |
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