THE DEMONSTRATION OF A TUMOR GROWTH-INHIBITING FACTOR FROM NORMAL HUMAN CONNECTIVE TISSUE

Extracts from fresh normal human connective tissue (rectus sheath) exhibited a decided inhibiting action on grafts of Rat Tumor 256 transplanted into test animals. There was complete inhibition of tumor growth in 66 per cent of the animals; there was a marked retardation in the rate of growth in ano...

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Autores principales: Morton, John J., Beers, Daniel N.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1935
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2133199/
https://www.ncbi.nlm.nih.gov/pubmed/19870346
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author Morton, John J.
Beers, Daniel N.
author_facet Morton, John J.
Beers, Daniel N.
author_sort Morton, John J.
collection PubMed
description Extracts from fresh normal human connective tissue (rectus sheath) exhibited a decided inhibiting action on grafts of Rat Tumor 256 transplanted into test animals. There was complete inhibition of tumor growth in 66 per cent of the animals; there was a marked retardation in the rate of growth in another 15 per cent, the tumors in these instances being much smaller than the controls transplanted at the same time. In only one experiment was there failure to obtain a lasting growth-inhibitory effect. The tumors in these animals (19 per cent) although showing an initial retardation in growth, apparently overcame the restraint and at the end of 5 weeks were larger than the control series. Extracts from fresh normal human muscle tissue, on the other hand, showed no such inhibiting action on grafts of Rat Tumor 256.
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spelling pubmed-21331992008-04-18 THE DEMONSTRATION OF A TUMOR GROWTH-INHIBITING FACTOR FROM NORMAL HUMAN CONNECTIVE TISSUE Morton, John J. Beers, Daniel N. J Exp Med Article Extracts from fresh normal human connective tissue (rectus sheath) exhibited a decided inhibiting action on grafts of Rat Tumor 256 transplanted into test animals. There was complete inhibition of tumor growth in 66 per cent of the animals; there was a marked retardation in the rate of growth in another 15 per cent, the tumors in these instances being much smaller than the controls transplanted at the same time. In only one experiment was there failure to obtain a lasting growth-inhibitory effect. The tumors in these animals (19 per cent) although showing an initial retardation in growth, apparently overcame the restraint and at the end of 5 weeks were larger than the control series. Extracts from fresh normal human muscle tissue, on the other hand, showed no such inhibiting action on grafts of Rat Tumor 256. The Rockefeller University Press 1935-01-01 /pmc/articles/PMC2133199/ /pubmed/19870346 Text en Copyright © Copyright, 1935, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Morton, John J.
Beers, Daniel N.
THE DEMONSTRATION OF A TUMOR GROWTH-INHIBITING FACTOR FROM NORMAL HUMAN CONNECTIVE TISSUE
title THE DEMONSTRATION OF A TUMOR GROWTH-INHIBITING FACTOR FROM NORMAL HUMAN CONNECTIVE TISSUE
title_full THE DEMONSTRATION OF A TUMOR GROWTH-INHIBITING FACTOR FROM NORMAL HUMAN CONNECTIVE TISSUE
title_fullStr THE DEMONSTRATION OF A TUMOR GROWTH-INHIBITING FACTOR FROM NORMAL HUMAN CONNECTIVE TISSUE
title_full_unstemmed THE DEMONSTRATION OF A TUMOR GROWTH-INHIBITING FACTOR FROM NORMAL HUMAN CONNECTIVE TISSUE
title_short THE DEMONSTRATION OF A TUMOR GROWTH-INHIBITING FACTOR FROM NORMAL HUMAN CONNECTIVE TISSUE
title_sort demonstration of a tumor growth-inhibiting factor from normal human connective tissue
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2133199/
https://www.ncbi.nlm.nih.gov/pubmed/19870346
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