THE CELLULAR REACTIONS TO ACETONE-SOLUBLE FAT FROM MYCOBACTERIA AND STREPTOCOCCI : THE EFFECT OF NEUTRALIZATION ON THE BIOLOGICAL ACTIVITY OF THE TUBERCULO-LIPOID AND OF THE PHTHIOIC ACID DERIVED FROM IT

1. The acetone-soluble fat of tubercle bacilli produces a profound cellular reaction when injected into normal animals. The reaction involves every type of connective tissue cell. Hemorrhage, formation of adhesions and of tubercular tissue occur. The extent of the reaction is roughly proportional to...

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Detalles Bibliográficos
Autores principales: Smithburn, Kenneth C., Sabin, Florence R.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1935
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2133254/
https://www.ncbi.nlm.nih.gov/pubmed/19870390
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author Smithburn, Kenneth C.
Sabin, Florence R.
author_facet Smithburn, Kenneth C.
Sabin, Florence R.
author_sort Smithburn, Kenneth C.
collection PubMed
description 1. The acetone-soluble fat of tubercle bacilli produces a profound cellular reaction when injected into normal animals. The reaction involves every type of connective tissue cell. Hemorrhage, formation of adhesions and of tubercular tissue occur. The extent of the reaction is roughly proportional to the amount of material injected. 2. The reaction induced by the lipoid is much less extensive and much simpler when the material is neutralized with alkali. Neutralization of the acetone-soluble fat, or of phthioic acid, does not diminish the tuberculogenic property. 3. Acetone-soluble fat from streptococci is likewise extremely irritating but does not produce tubercular tissue.
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spelling pubmed-21332542008-04-18 THE CELLULAR REACTIONS TO ACETONE-SOLUBLE FAT FROM MYCOBACTERIA AND STREPTOCOCCI : THE EFFECT OF NEUTRALIZATION ON THE BIOLOGICAL ACTIVITY OF THE TUBERCULO-LIPOID AND OF THE PHTHIOIC ACID DERIVED FROM IT Smithburn, Kenneth C. Sabin, Florence R. J Exp Med Article 1. The acetone-soluble fat of tubercle bacilli produces a profound cellular reaction when injected into normal animals. The reaction involves every type of connective tissue cell. Hemorrhage, formation of adhesions and of tubercular tissue occur. The extent of the reaction is roughly proportional to the amount of material injected. 2. The reaction induced by the lipoid is much less extensive and much simpler when the material is neutralized with alkali. Neutralization of the acetone-soluble fat, or of phthioic acid, does not diminish the tuberculogenic property. 3. Acetone-soluble fat from streptococci is likewise extremely irritating but does not produce tubercular tissue. The Rockefeller University Press 1935-05-31 /pmc/articles/PMC2133254/ /pubmed/19870390 Text en Copyright © Copyright, 1935, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Smithburn, Kenneth C.
Sabin, Florence R.
THE CELLULAR REACTIONS TO ACETONE-SOLUBLE FAT FROM MYCOBACTERIA AND STREPTOCOCCI : THE EFFECT OF NEUTRALIZATION ON THE BIOLOGICAL ACTIVITY OF THE TUBERCULO-LIPOID AND OF THE PHTHIOIC ACID DERIVED FROM IT
title THE CELLULAR REACTIONS TO ACETONE-SOLUBLE FAT FROM MYCOBACTERIA AND STREPTOCOCCI : THE EFFECT OF NEUTRALIZATION ON THE BIOLOGICAL ACTIVITY OF THE TUBERCULO-LIPOID AND OF THE PHTHIOIC ACID DERIVED FROM IT
title_full THE CELLULAR REACTIONS TO ACETONE-SOLUBLE FAT FROM MYCOBACTERIA AND STREPTOCOCCI : THE EFFECT OF NEUTRALIZATION ON THE BIOLOGICAL ACTIVITY OF THE TUBERCULO-LIPOID AND OF THE PHTHIOIC ACID DERIVED FROM IT
title_fullStr THE CELLULAR REACTIONS TO ACETONE-SOLUBLE FAT FROM MYCOBACTERIA AND STREPTOCOCCI : THE EFFECT OF NEUTRALIZATION ON THE BIOLOGICAL ACTIVITY OF THE TUBERCULO-LIPOID AND OF THE PHTHIOIC ACID DERIVED FROM IT
title_full_unstemmed THE CELLULAR REACTIONS TO ACETONE-SOLUBLE FAT FROM MYCOBACTERIA AND STREPTOCOCCI : THE EFFECT OF NEUTRALIZATION ON THE BIOLOGICAL ACTIVITY OF THE TUBERCULO-LIPOID AND OF THE PHTHIOIC ACID DERIVED FROM IT
title_short THE CELLULAR REACTIONS TO ACETONE-SOLUBLE FAT FROM MYCOBACTERIA AND STREPTOCOCCI : THE EFFECT OF NEUTRALIZATION ON THE BIOLOGICAL ACTIVITY OF THE TUBERCULO-LIPOID AND OF THE PHTHIOIC ACID DERIVED FROM IT
title_sort cellular reactions to acetone-soluble fat from mycobacteria and streptococci : the effect of neutralization on the biological activity of the tuberculo-lipoid and of the phthioic acid derived from it
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2133254/
https://www.ncbi.nlm.nih.gov/pubmed/19870390
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