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INFECTIOUS FIBROMA OF RABBITS : III. THE SERIAL TRANSMISSION OF VIRUS MYXOMATOSUM IN COTTONTAIL RABBITS, AND CROSS-IMMUNITY TESTS WITH THE FIBROMA VIRUS

In the experiments presented, Virus myxomatosum was observed to produce only a localized fibromatous or myxomatous orchitis when injected into the testicles of cottontail rabbits. This type of disease was quite unlike the acute fatal illness which the virus caused in domestic rabbits. 10 serial pass...

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Detalles Bibliográficos
Autor principal: Shope, Richard E.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1936
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2133319/
https://www.ncbi.nlm.nih.gov/pubmed/19870458
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author Shope, Richard E.
author_facet Shope, Richard E.
author_sort Shope, Richard E.
collection PubMed
description In the experiments presented, Virus myxomatosum was observed to produce only a localized fibromatous or myxomatous orchitis when injected into the testicles of cottontail rabbits. This type of disease was quite unlike the acute fatal illness which the virus caused in domestic rabbits. 10 serial passages of Virus myxomatosum through cottontail rabbits, covering a total elapsed time of 140 days, failed to alter its pathogenicity for domestic rabbits. Although it proved impossible to convert the myxoma virus into fibroma virus by serial passage in cottontail rabbits, it was found that these animals, recovered from myxoma, had a solid resistance to infection with the fibroma virus. Furthermore, their sera possessed neutralizing antibodies effective against the fibroma virus as well as Virus myxomatosum. A similar cross-immunological relationship was observed in the cases of domestic rabbits that had survived an attack of infectious myxoma.
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spelling pubmed-21333192008-04-18 INFECTIOUS FIBROMA OF RABBITS : III. THE SERIAL TRANSMISSION OF VIRUS MYXOMATOSUM IN COTTONTAIL RABBITS, AND CROSS-IMMUNITY TESTS WITH THE FIBROMA VIRUS Shope, Richard E. J Exp Med Article In the experiments presented, Virus myxomatosum was observed to produce only a localized fibromatous or myxomatous orchitis when injected into the testicles of cottontail rabbits. This type of disease was quite unlike the acute fatal illness which the virus caused in domestic rabbits. 10 serial passages of Virus myxomatosum through cottontail rabbits, covering a total elapsed time of 140 days, failed to alter its pathogenicity for domestic rabbits. Although it proved impossible to convert the myxoma virus into fibroma virus by serial passage in cottontail rabbits, it was found that these animals, recovered from myxoma, had a solid resistance to infection with the fibroma virus. Furthermore, their sera possessed neutralizing antibodies effective against the fibroma virus as well as Virus myxomatosum. A similar cross-immunological relationship was observed in the cases of domestic rabbits that had survived an attack of infectious myxoma. The Rockefeller University Press 1936-01-01 /pmc/articles/PMC2133319/ /pubmed/19870458 Text en Copyright © Copyright, 1936, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Shope, Richard E.
INFECTIOUS FIBROMA OF RABBITS : III. THE SERIAL TRANSMISSION OF VIRUS MYXOMATOSUM IN COTTONTAIL RABBITS, AND CROSS-IMMUNITY TESTS WITH THE FIBROMA VIRUS
title INFECTIOUS FIBROMA OF RABBITS : III. THE SERIAL TRANSMISSION OF VIRUS MYXOMATOSUM IN COTTONTAIL RABBITS, AND CROSS-IMMUNITY TESTS WITH THE FIBROMA VIRUS
title_full INFECTIOUS FIBROMA OF RABBITS : III. THE SERIAL TRANSMISSION OF VIRUS MYXOMATOSUM IN COTTONTAIL RABBITS, AND CROSS-IMMUNITY TESTS WITH THE FIBROMA VIRUS
title_fullStr INFECTIOUS FIBROMA OF RABBITS : III. THE SERIAL TRANSMISSION OF VIRUS MYXOMATOSUM IN COTTONTAIL RABBITS, AND CROSS-IMMUNITY TESTS WITH THE FIBROMA VIRUS
title_full_unstemmed INFECTIOUS FIBROMA OF RABBITS : III. THE SERIAL TRANSMISSION OF VIRUS MYXOMATOSUM IN COTTONTAIL RABBITS, AND CROSS-IMMUNITY TESTS WITH THE FIBROMA VIRUS
title_short INFECTIOUS FIBROMA OF RABBITS : III. THE SERIAL TRANSMISSION OF VIRUS MYXOMATOSUM IN COTTONTAIL RABBITS, AND CROSS-IMMUNITY TESTS WITH THE FIBROMA VIRUS
title_sort infectious fibroma of rabbits : iii. the serial transmission of virus myxomatosum in cottontail rabbits, and cross-immunity tests with the fibroma virus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2133319/
https://www.ncbi.nlm.nih.gov/pubmed/19870458
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