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A CHANGE IN RABBIT FIBROMA VIRUS SUGGESTING MUTATION : I. EXPERIMENTS ON DOMESTIC RABBITS
A strain of rabbit fibroma is described causing in inoculated animals acute inflammatory lesions very different from the fibroma-like growths induced by the original strain. The new inflammatory strain cross-immunised with the normal strain but not with various other viruses. Efforts at changing one...
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
1936
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2133331/ https://www.ncbi.nlm.nih.gov/pubmed/19870463 |
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author | Andrewes, C. H. |
author_facet | Andrewes, C. H. |
author_sort | Andrewes, C. H. |
collection | PubMed |
description | A strain of rabbit fibroma is described causing in inoculated animals acute inflammatory lesions very different from the fibroma-like growths induced by the original strain. The new inflammatory strain cross-immunised with the normal strain but not with various other viruses. Efforts at changing one strain into the other were unsuccessful. Another, referred to as the changed, strain produced lesions of mixed character, partly inflammatory, partly fibromatous; it continued to behave in this way through numerous passages. An artificial mixture of inflammatory and fibromatous viruses behaved in all respects like the changed strain. Discussion of the significance of the findings is reserved for a separate paper (3) where the facts can be considered in relation to those described by Shope (2). |
format | Text |
id | pubmed-2133331 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1936 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21333312008-04-18 A CHANGE IN RABBIT FIBROMA VIRUS SUGGESTING MUTATION : I. EXPERIMENTS ON DOMESTIC RABBITS Andrewes, C. H. J Exp Med Article A strain of rabbit fibroma is described causing in inoculated animals acute inflammatory lesions very different from the fibroma-like growths induced by the original strain. The new inflammatory strain cross-immunised with the normal strain but not with various other viruses. Efforts at changing one strain into the other were unsuccessful. Another, referred to as the changed, strain produced lesions of mixed character, partly inflammatory, partly fibromatous; it continued to behave in this way through numerous passages. An artificial mixture of inflammatory and fibromatous viruses behaved in all respects like the changed strain. Discussion of the significance of the findings is reserved for a separate paper (3) where the facts can be considered in relation to those described by Shope (2). The Rockefeller University Press 1936-01-31 /pmc/articles/PMC2133331/ /pubmed/19870463 Text en Copyright © Copyright, 1936, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Andrewes, C. H. A CHANGE IN RABBIT FIBROMA VIRUS SUGGESTING MUTATION : I. EXPERIMENTS ON DOMESTIC RABBITS |
title | A CHANGE IN RABBIT FIBROMA VIRUS SUGGESTING MUTATION : I. EXPERIMENTS ON DOMESTIC RABBITS |
title_full | A CHANGE IN RABBIT FIBROMA VIRUS SUGGESTING MUTATION : I. EXPERIMENTS ON DOMESTIC RABBITS |
title_fullStr | A CHANGE IN RABBIT FIBROMA VIRUS SUGGESTING MUTATION : I. EXPERIMENTS ON DOMESTIC RABBITS |
title_full_unstemmed | A CHANGE IN RABBIT FIBROMA VIRUS SUGGESTING MUTATION : I. EXPERIMENTS ON DOMESTIC RABBITS |
title_short | A CHANGE IN RABBIT FIBROMA VIRUS SUGGESTING MUTATION : I. EXPERIMENTS ON DOMESTIC RABBITS |
title_sort | change in rabbit fibroma virus suggesting mutation : i. experiments on domestic rabbits |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2133331/ https://www.ncbi.nlm.nih.gov/pubmed/19870463 |
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