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PERSISTENCE OF LYMPHOCYTIC CHORIOMENINGITIS VIRUS IN IMMUNE ANIMALS AND ITS RELATION TO IMMUNITY

In some apparently healthy mice the virus of lymphocytic choriomeningitis persisted for a considerable period of time after recovery, in the blood, urine, and nasal secretions, while in other mice it soon became undemonstrable. It is possible that the persistence of the virus is due to lesions in th...

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Detalles Bibliográficos
Autor principal: Traub, Erich
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1936
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2133407/
https://www.ncbi.nlm.nih.gov/pubmed/19870509
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author Traub, Erich
author_facet Traub, Erich
author_sort Traub, Erich
collection PubMed
description In some apparently healthy mice the virus of lymphocytic choriomeningitis persisted for a considerable period of time after recovery, in the blood, urine, and nasal secretions, while in other mice it soon became undemonstrable. It is possible that the persistence of the virus is due to lesions in the lungs, liver, and kidneys. The immunity to lymphocytic choriomeningitis in mice does not seem to depend upon the presence of virus in the blood and the organs tested. No antivirus was detected in sera from several solidly immune mice, which fact suggests that circulating antivirus plays no important part in their immunity. Leucocytes also seem to be no essential factor in this immunity, which probably is closely linked with the tissues. The urine of guinea pigs which had recovered from severe attacks of lymphocytic choriomeningitis contained virus for a few weeks after recovery, while that from mild cases contained no virus. Virus was never demonstrated in the blood of immune guinea pigs. Antivirus was readily detected in it.
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spelling pubmed-21334072008-04-18 PERSISTENCE OF LYMPHOCYTIC CHORIOMENINGITIS VIRUS IN IMMUNE ANIMALS AND ITS RELATION TO IMMUNITY Traub, Erich J Exp Med Article In some apparently healthy mice the virus of lymphocytic choriomeningitis persisted for a considerable period of time after recovery, in the blood, urine, and nasal secretions, while in other mice it soon became undemonstrable. It is possible that the persistence of the virus is due to lesions in the lungs, liver, and kidneys. The immunity to lymphocytic choriomeningitis in mice does not seem to depend upon the presence of virus in the blood and the organs tested. No antivirus was detected in sera from several solidly immune mice, which fact suggests that circulating antivirus plays no important part in their immunity. Leucocytes also seem to be no essential factor in this immunity, which probably is closely linked with the tissues. The urine of guinea pigs which had recovered from severe attacks of lymphocytic choriomeningitis contained virus for a few weeks after recovery, while that from mild cases contained no virus. Virus was never demonstrated in the blood of immune guinea pigs. Antivirus was readily detected in it. The Rockefeller University Press 1936-05-31 /pmc/articles/PMC2133407/ /pubmed/19870509 Text en Copyright © Copyright, 1936, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Traub, Erich
PERSISTENCE OF LYMPHOCYTIC CHORIOMENINGITIS VIRUS IN IMMUNE ANIMALS AND ITS RELATION TO IMMUNITY
title PERSISTENCE OF LYMPHOCYTIC CHORIOMENINGITIS VIRUS IN IMMUNE ANIMALS AND ITS RELATION TO IMMUNITY
title_full PERSISTENCE OF LYMPHOCYTIC CHORIOMENINGITIS VIRUS IN IMMUNE ANIMALS AND ITS RELATION TO IMMUNITY
title_fullStr PERSISTENCE OF LYMPHOCYTIC CHORIOMENINGITIS VIRUS IN IMMUNE ANIMALS AND ITS RELATION TO IMMUNITY
title_full_unstemmed PERSISTENCE OF LYMPHOCYTIC CHORIOMENINGITIS VIRUS IN IMMUNE ANIMALS AND ITS RELATION TO IMMUNITY
title_short PERSISTENCE OF LYMPHOCYTIC CHORIOMENINGITIS VIRUS IN IMMUNE ANIMALS AND ITS RELATION TO IMMUNITY
title_sort persistence of lymphocytic choriomeningitis virus in immune animals and its relation to immunity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2133407/
https://www.ncbi.nlm.nih.gov/pubmed/19870509
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