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TISSUE CULTURE STUDIES ON BACTERIAL HYPERSENSITIVITY : II. REACTIONS OF TISSUES FROM GUINEA PIGS INFECTED WITH GROUP C HEMOLYTIC STREPTOCOCCI

1. Guinea pigs infected with naturally pathogenic hemolytic streptococci (group C—Lancefield) develop a low grade chronic type of disease characterized chiefly by purulent lymphadenitis. 2. Cutaneous hyperreactivity to a crude streptococcal extract invariably occurred during the course of this infec...

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Detalles Bibliográficos
Autor principal: Moen, Johannes K.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1936
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2133423/
https://www.ncbi.nlm.nih.gov/pubmed/19870540
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author Moen, Johannes K.
author_facet Moen, Johannes K.
author_sort Moen, Johannes K.
collection PubMed
description 1. Guinea pigs infected with naturally pathogenic hemolytic streptococci (group C—Lancefield) develop a low grade chronic type of disease characterized chiefly by purulent lymphadenitis. 2. Cutaneous hyperreactivity to a crude streptococcal extract invariably occurred during the course of this infection. 3. Production of antibodies (precipitins and agglutinins) was studied. 4. The hemolytic streptococcal extract had a specific toxic effect, when tested in vitro, on cells from infected animals; this was shown by microscopic evidence of cellular injury, and by quantitative inhibition of cellular migration and growth. The specificity of the reaction was proven by testing with other cytotoxic substances. 5. There was no parallelism between skin hypersensitivity and humoral antibody titer. 6. There was no correlation between the degree of skin reactivity to the bacterial extract and the degree of sensitivity of splenic cells to the toxic action of the same extract in vitro. 7. Comparison of cellular sensitivity to tuberculin with cellular sensitivity to streptococcal extract in cultures of guinea pig tissues showed that the former was more intense and was more persistent on prolonged growth in vitro.
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spelling pubmed-21334232008-04-18 TISSUE CULTURE STUDIES ON BACTERIAL HYPERSENSITIVITY : II. REACTIONS OF TISSUES FROM GUINEA PIGS INFECTED WITH GROUP C HEMOLYTIC STREPTOCOCCI Moen, Johannes K. J Exp Med Article 1. Guinea pigs infected with naturally pathogenic hemolytic streptococci (group C—Lancefield) develop a low grade chronic type of disease characterized chiefly by purulent lymphadenitis. 2. Cutaneous hyperreactivity to a crude streptococcal extract invariably occurred during the course of this infection. 3. Production of antibodies (precipitins and agglutinins) was studied. 4. The hemolytic streptococcal extract had a specific toxic effect, when tested in vitro, on cells from infected animals; this was shown by microscopic evidence of cellular injury, and by quantitative inhibition of cellular migration and growth. The specificity of the reaction was proven by testing with other cytotoxic substances. 5. There was no parallelism between skin hypersensitivity and humoral antibody titer. 6. There was no correlation between the degree of skin reactivity to the bacterial extract and the degree of sensitivity of splenic cells to the toxic action of the same extract in vitro. 7. Comparison of cellular sensitivity to tuberculin with cellular sensitivity to streptococcal extract in cultures of guinea pig tissues showed that the former was more intense and was more persistent on prolonged growth in vitro. The Rockefeller University Press 1936-08-31 /pmc/articles/PMC2133423/ /pubmed/19870540 Text en Copyright © Copyright, 1936, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Moen, Johannes K.
TISSUE CULTURE STUDIES ON BACTERIAL HYPERSENSITIVITY : II. REACTIONS OF TISSUES FROM GUINEA PIGS INFECTED WITH GROUP C HEMOLYTIC STREPTOCOCCI
title TISSUE CULTURE STUDIES ON BACTERIAL HYPERSENSITIVITY : II. REACTIONS OF TISSUES FROM GUINEA PIGS INFECTED WITH GROUP C HEMOLYTIC STREPTOCOCCI
title_full TISSUE CULTURE STUDIES ON BACTERIAL HYPERSENSITIVITY : II. REACTIONS OF TISSUES FROM GUINEA PIGS INFECTED WITH GROUP C HEMOLYTIC STREPTOCOCCI
title_fullStr TISSUE CULTURE STUDIES ON BACTERIAL HYPERSENSITIVITY : II. REACTIONS OF TISSUES FROM GUINEA PIGS INFECTED WITH GROUP C HEMOLYTIC STREPTOCOCCI
title_full_unstemmed TISSUE CULTURE STUDIES ON BACTERIAL HYPERSENSITIVITY : II. REACTIONS OF TISSUES FROM GUINEA PIGS INFECTED WITH GROUP C HEMOLYTIC STREPTOCOCCI
title_short TISSUE CULTURE STUDIES ON BACTERIAL HYPERSENSITIVITY : II. REACTIONS OF TISSUES FROM GUINEA PIGS INFECTED WITH GROUP C HEMOLYTIC STREPTOCOCCI
title_sort tissue culture studies on bacterial hypersensitivity : ii. reactions of tissues from guinea pigs infected with group c hemolytic streptococci
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2133423/
https://www.ncbi.nlm.nih.gov/pubmed/19870540
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