THE PROTECTIVE ACTION OF TYPE I ANTIPNEUMOCOCCUS SERUM IN MICE : V. THE EFFECT OF ADDED LIPIDS ON THE PROTECTIVE MECHANISM

1. The addition of small amounts of cholesterol and of cephalin reduces markedly the protective action of antipneumococcus horse serum. 2. These lipids do not affect the protective action of antipneumococcus rabbit serum. 3. These findings may be explained (a)by the selective adsorption of lipid on...

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Autores principales: Goodner, Kenneth, Horsfall, Frank L.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1936
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2133428/
https://www.ncbi.nlm.nih.gov/pubmed/19870542
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author Goodner, Kenneth
Horsfall, Frank L.
author_facet Goodner, Kenneth
Horsfall, Frank L.
author_sort Goodner, Kenneth
collection PubMed
description 1. The addition of small amounts of cholesterol and of cephalin reduces markedly the protective action of antipneumococcus horse serum. 2. These lipids do not affect the protective action of antipneumococcus rabbit serum. 3. These findings may be explained (a)by the selective adsorption of lipid on the antigen-antibody complex, and (b) by certain lipid antagonisms. 4. The failure of large amounts of immune horse serum to protect mice against pneumococcus infection is explicable on the basis of selective participation of lipids dependent upon the species from which the antibody is derived. 5. The lipids modify the results of protection tests only through participation in the process of specific sensitization.
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spelling pubmed-21334282008-04-18 THE PROTECTIVE ACTION OF TYPE I ANTIPNEUMOCOCCUS SERUM IN MICE : V. THE EFFECT OF ADDED LIPIDS ON THE PROTECTIVE MECHANISM Goodner, Kenneth Horsfall, Frank L. J Exp Med Article 1. The addition of small amounts of cholesterol and of cephalin reduces markedly the protective action of antipneumococcus horse serum. 2. These lipids do not affect the protective action of antipneumococcus rabbit serum. 3. These findings may be explained (a)by the selective adsorption of lipid on the antigen-antibody complex, and (b) by certain lipid antagonisms. 4. The failure of large amounts of immune horse serum to protect mice against pneumococcus infection is explicable on the basis of selective participation of lipids dependent upon the species from which the antibody is derived. 5. The lipids modify the results of protection tests only through participation in the process of specific sensitization. The Rockefeller University Press 1936-08-31 /pmc/articles/PMC2133428/ /pubmed/19870542 Text en Copyright © Copyright, 1936, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Goodner, Kenneth
Horsfall, Frank L.
THE PROTECTIVE ACTION OF TYPE I ANTIPNEUMOCOCCUS SERUM IN MICE : V. THE EFFECT OF ADDED LIPIDS ON THE PROTECTIVE MECHANISM
title THE PROTECTIVE ACTION OF TYPE I ANTIPNEUMOCOCCUS SERUM IN MICE : V. THE EFFECT OF ADDED LIPIDS ON THE PROTECTIVE MECHANISM
title_full THE PROTECTIVE ACTION OF TYPE I ANTIPNEUMOCOCCUS SERUM IN MICE : V. THE EFFECT OF ADDED LIPIDS ON THE PROTECTIVE MECHANISM
title_fullStr THE PROTECTIVE ACTION OF TYPE I ANTIPNEUMOCOCCUS SERUM IN MICE : V. THE EFFECT OF ADDED LIPIDS ON THE PROTECTIVE MECHANISM
title_full_unstemmed THE PROTECTIVE ACTION OF TYPE I ANTIPNEUMOCOCCUS SERUM IN MICE : V. THE EFFECT OF ADDED LIPIDS ON THE PROTECTIVE MECHANISM
title_short THE PROTECTIVE ACTION OF TYPE I ANTIPNEUMOCOCCUS SERUM IN MICE : V. THE EFFECT OF ADDED LIPIDS ON THE PROTECTIVE MECHANISM
title_sort protective action of type i antipneumococcus serum in mice : v. the effect of added lipids on the protective mechanism
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2133428/
https://www.ncbi.nlm.nih.gov/pubmed/19870542
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