THE STANDARDIZATION OF LONGEVITY AGAINST DOSE IN EXPERIMENTAL TUBERCULOSIS BY INTRACEREBRAL INOCULATION

Intracerebral inoculation of tuberde bacilli into normal guinea pigs induces acute meningoencephalitis with minor metastatic lesions. The disease is fatal in a relatively short time and is characterized by a rather typical succession of symptoms and a fairly characteristic temperature curve. The dis...

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Detalles Bibliográficos
Autor principal: Smithburn, Kenneth C.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1936
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2133452/
https://www.ncbi.nlm.nih.gov/pubmed/19870568
Descripción
Sumario:Intracerebral inoculation of tuberde bacilli into normal guinea pigs induces acute meningoencephalitis with minor metastatic lesions. The disease is fatal in a relatively short time and is characterized by a rather typical succession of symptoms and a fairly characteristic temperature curve. The disease is produced by very small numbers of bacilli; and under standard conditions, survival time is so uniform as to make possible quantitative or titration experiments. Certain possible applications of the method are discussed.

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