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THE PRODUCTION OF BLOOD PLATELETS IN THE LUNGS

1. A new fixing solution is described, which preserves the platelets and prevents contact hemolysis of the erythrocytes, so that counts of both corpuscles may be made in the same preparation. 2. Comparative counts of platelets in arteries and veins show that arterial blood contains a larger number o...

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Detalles Bibliográficos
Autores principales: Howell, W. H., Donahue, D. D.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1937
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2133484/
https://www.ncbi.nlm.nih.gov/pubmed/19870594
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author Howell, W. H.
Donahue, D. D.
author_facet Howell, W. H.
Donahue, D. D.
author_sort Howell, W. H.
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description 1. A new fixing solution is described, which preserves the platelets and prevents contact hemolysis of the erythrocytes, so that counts of both corpuscles may be made in the same preparation. 2. Comparative counts of platelets in arteries and veins show that arterial blood contains a larger number of platelets than venous blood. This difference is accentuated under experimental conditions that cause a reduction in the number of platelets. It is concluded that new platelets are added to the blood in the capillary areas of the lungs, and that there is a corresponding destruction of platelets as the blood passes through the capillary areas of the systemic circulation. 3. Perfusion of the lungs with a platelet-preserving solution, compared with that of other organs, gives evidence of the existence of a source of platelet material in the lungs. 4. Histological examination of the lungs with a technique adequate to give a differential staining of platelet material demonstrates the presence of giant cells in the lungs, and supports the view that they are active in the production of platelets. 5. In extrauterine life giant cells are concentrated in the marrow and the lungs, with the maximum of their activity in platelet production in the lungs.
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spelling pubmed-21334842008-04-18 THE PRODUCTION OF BLOOD PLATELETS IN THE LUNGS Howell, W. H. Donahue, D. D. J Exp Med Article 1. A new fixing solution is described, which preserves the platelets and prevents contact hemolysis of the erythrocytes, so that counts of both corpuscles may be made in the same preparation. 2. Comparative counts of platelets in arteries and veins show that arterial blood contains a larger number of platelets than venous blood. This difference is accentuated under experimental conditions that cause a reduction in the number of platelets. It is concluded that new platelets are added to the blood in the capillary areas of the lungs, and that there is a corresponding destruction of platelets as the blood passes through the capillary areas of the systemic circulation. 3. Perfusion of the lungs with a platelet-preserving solution, compared with that of other organs, gives evidence of the existence of a source of platelet material in the lungs. 4. Histological examination of the lungs with a technique adequate to give a differential staining of platelet material demonstrates the presence of giant cells in the lungs, and supports the view that they are active in the production of platelets. 5. In extrauterine life giant cells are concentrated in the marrow and the lungs, with the maximum of their activity in platelet production in the lungs. The Rockefeller University Press 1937-01-31 /pmc/articles/PMC2133484/ /pubmed/19870594 Text en Copyright © Copyright, 1937, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Howell, W. H.
Donahue, D. D.
THE PRODUCTION OF BLOOD PLATELETS IN THE LUNGS
title THE PRODUCTION OF BLOOD PLATELETS IN THE LUNGS
title_full THE PRODUCTION OF BLOOD PLATELETS IN THE LUNGS
title_fullStr THE PRODUCTION OF BLOOD PLATELETS IN THE LUNGS
title_full_unstemmed THE PRODUCTION OF BLOOD PLATELETS IN THE LUNGS
title_short THE PRODUCTION OF BLOOD PLATELETS IN THE LUNGS
title_sort production of blood platelets in the lungs
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2133484/
https://www.ncbi.nlm.nih.gov/pubmed/19870594
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