THE DISTRIBUTION IN THE BLOOD AND LYMPH OF PNEUMOCOCCUS TYPE III INJECTED INTRAVENOUSLY IN RABBITS, AND THE EFFECT OF TREATMENT WITH SPECIFIC ANTISERUM ON THE INFECTION OF THE LYMPH

Experiments are described which show that in rabbits infected intravenously with virulent Type III pneumococci, these organisms are found not only in the thoracic duct lymph, as previously reported, but also in lymph from the cervical and leg lymphatics. The nonmotile bacteria must have crossed both...

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Detalles Bibliográficos
Autores principales: Field, Madeleine E., Shaffer, Morris F., Enders, John F., Drinker, Cecil K.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1937
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2133505/
https://www.ncbi.nlm.nih.gov/pubmed/19870612
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author Field, Madeleine E.
Shaffer, Morris F.
Enders, John F.
Drinker, Cecil K.
author_facet Field, Madeleine E.
Shaffer, Morris F.
Enders, John F.
Drinker, Cecil K.
author_sort Field, Madeleine E.
collection PubMed
description Experiments are described which show that in rabbits infected intravenously with virulent Type III pneumococci, these organisms are found not only in the thoracic duct lymph, as previously reported, but also in lymph from the cervical and leg lymphatics. The nonmotile bacteria must have crossed both vascular and lymphatic endothelium in reaching the lymph. Intracellular transportation by phagocytes is apparently not the means by which this is effected. The intravenous and intraperitoneal injection of large amounts of homologous type-specific antibody fails even after many hours to terminate or permanently reduce the pneumococcal infection of the lymph. The failure of antiserum to sterilize the lymph is discussed.
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spelling pubmed-21335052008-04-18 THE DISTRIBUTION IN THE BLOOD AND LYMPH OF PNEUMOCOCCUS TYPE III INJECTED INTRAVENOUSLY IN RABBITS, AND THE EFFECT OF TREATMENT WITH SPECIFIC ANTISERUM ON THE INFECTION OF THE LYMPH Field, Madeleine E. Shaffer, Morris F. Enders, John F. Drinker, Cecil K. J Exp Med Article Experiments are described which show that in rabbits infected intravenously with virulent Type III pneumococci, these organisms are found not only in the thoracic duct lymph, as previously reported, but also in lymph from the cervical and leg lymphatics. The nonmotile bacteria must have crossed both vascular and lymphatic endothelium in reaching the lymph. Intracellular transportation by phagocytes is apparently not the means by which this is effected. The intravenous and intraperitoneal injection of large amounts of homologous type-specific antibody fails even after many hours to terminate or permanently reduce the pneumococcal infection of the lymph. The failure of antiserum to sterilize the lymph is discussed. The Rockefeller University Press 1937-03-31 /pmc/articles/PMC2133505/ /pubmed/19870612 Text en Copyright © Copyright, 1937, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Field, Madeleine E.
Shaffer, Morris F.
Enders, John F.
Drinker, Cecil K.
THE DISTRIBUTION IN THE BLOOD AND LYMPH OF PNEUMOCOCCUS TYPE III INJECTED INTRAVENOUSLY IN RABBITS, AND THE EFFECT OF TREATMENT WITH SPECIFIC ANTISERUM ON THE INFECTION OF THE LYMPH
title THE DISTRIBUTION IN THE BLOOD AND LYMPH OF PNEUMOCOCCUS TYPE III INJECTED INTRAVENOUSLY IN RABBITS, AND THE EFFECT OF TREATMENT WITH SPECIFIC ANTISERUM ON THE INFECTION OF THE LYMPH
title_full THE DISTRIBUTION IN THE BLOOD AND LYMPH OF PNEUMOCOCCUS TYPE III INJECTED INTRAVENOUSLY IN RABBITS, AND THE EFFECT OF TREATMENT WITH SPECIFIC ANTISERUM ON THE INFECTION OF THE LYMPH
title_fullStr THE DISTRIBUTION IN THE BLOOD AND LYMPH OF PNEUMOCOCCUS TYPE III INJECTED INTRAVENOUSLY IN RABBITS, AND THE EFFECT OF TREATMENT WITH SPECIFIC ANTISERUM ON THE INFECTION OF THE LYMPH
title_full_unstemmed THE DISTRIBUTION IN THE BLOOD AND LYMPH OF PNEUMOCOCCUS TYPE III INJECTED INTRAVENOUSLY IN RABBITS, AND THE EFFECT OF TREATMENT WITH SPECIFIC ANTISERUM ON THE INFECTION OF THE LYMPH
title_short THE DISTRIBUTION IN THE BLOOD AND LYMPH OF PNEUMOCOCCUS TYPE III INJECTED INTRAVENOUSLY IN RABBITS, AND THE EFFECT OF TREATMENT WITH SPECIFIC ANTISERUM ON THE INFECTION OF THE LYMPH
title_sort distribution in the blood and lymph of pneumococcus type iii injected intravenously in rabbits, and the effect of treatment with specific antiserum on the infection of the lymph
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2133505/
https://www.ncbi.nlm.nih.gov/pubmed/19870612
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