STUDIES ON HAEMOPHILUS INFLUENZAE : I. INFECTION OF MICE WITH MUCIN SUSPENSIONS OF THE ORGANISM

1. It has been shown that the ability of virulent S. influenzae to kill mice is enhanced by suspending the organism in mucin. 2. The occurrence of a true infection characterized by in vivo multiplication of the organism has been established. 3. The necessity for using a pure inbred strain of mice fo...

Descripción completa

Detalles Bibliográficos
Autores principales: Fothergill, LeRoy D., Dingle, John H., Chandler, Caroline A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1937
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2133510/
https://www.ncbi.nlm.nih.gov/pubmed/19870630
_version_ 1782142686257479680
author Fothergill, LeRoy D.
Dingle, John H.
Chandler, Caroline A.
author_facet Fothergill, LeRoy D.
Dingle, John H.
Chandler, Caroline A.
author_sort Fothergill, LeRoy D.
collection PubMed
description 1. It has been shown that the ability of virulent S. influenzae to kill mice is enhanced by suspending the organism in mucin. 2. The occurrence of a true infection characterized by in vivo multiplication of the organism has been established. 3. The necessity for using a pure inbred strain of mice for this type of study has been confirmed. 4. The increase in mucin virulence of a strain of H. influenzae by repeated passage through mice has been shown. 5. The usefulness of this method in passive immunization studies has been demonstrated.
format Text
id pubmed-2133510
institution National Center for Biotechnology Information
language English
publishDate 1937
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21335102008-04-18 STUDIES ON HAEMOPHILUS INFLUENZAE : I. INFECTION OF MICE WITH MUCIN SUSPENSIONS OF THE ORGANISM Fothergill, LeRoy D. Dingle, John H. Chandler, Caroline A. J Exp Med Article 1. It has been shown that the ability of virulent S. influenzae to kill mice is enhanced by suspending the organism in mucin. 2. The occurrence of a true infection characterized by in vivo multiplication of the organism has been established. 3. The necessity for using a pure inbred strain of mice for this type of study has been confirmed. 4. The increase in mucin virulence of a strain of H. influenzae by repeated passage through mice has been shown. 5. The usefulness of this method in passive immunization studies has been demonstrated. The Rockefeller University Press 1937-04-30 /pmc/articles/PMC2133510/ /pubmed/19870630 Text en Copyright © Copyright, 1937, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Fothergill, LeRoy D.
Dingle, John H.
Chandler, Caroline A.
STUDIES ON HAEMOPHILUS INFLUENZAE : I. INFECTION OF MICE WITH MUCIN SUSPENSIONS OF THE ORGANISM
title STUDIES ON HAEMOPHILUS INFLUENZAE : I. INFECTION OF MICE WITH MUCIN SUSPENSIONS OF THE ORGANISM
title_full STUDIES ON HAEMOPHILUS INFLUENZAE : I. INFECTION OF MICE WITH MUCIN SUSPENSIONS OF THE ORGANISM
title_fullStr STUDIES ON HAEMOPHILUS INFLUENZAE : I. INFECTION OF MICE WITH MUCIN SUSPENSIONS OF THE ORGANISM
title_full_unstemmed STUDIES ON HAEMOPHILUS INFLUENZAE : I. INFECTION OF MICE WITH MUCIN SUSPENSIONS OF THE ORGANISM
title_short STUDIES ON HAEMOPHILUS INFLUENZAE : I. INFECTION OF MICE WITH MUCIN SUSPENSIONS OF THE ORGANISM
title_sort studies on haemophilus influenzae : i. infection of mice with mucin suspensions of the organism
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2133510/
https://www.ncbi.nlm.nih.gov/pubmed/19870630
work_keys_str_mv AT fothergillleroyd studiesonhaemophilusinfluenzaeiinfectionofmicewithmucinsuspensionsoftheorganism
AT dinglejohnh studiesonhaemophilusinfluenzaeiinfectionofmicewithmucinsuspensionsoftheorganism
AT chandlercarolinea studiesonhaemophilusinfluenzaeiinfectionofmicewithmucinsuspensionsoftheorganism

Ejemplares similares