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ANAPHYLAXIS IN THE ISOLATED HEART
The isolated hearts of guinea pigs sensitized to horse serum have been shown to react characteristically upon exposure to small amounts of antigen. The cardiac rate is temporarily accelerated and transient alterations in amplitude of contraction are to be observed. Electrocardiographic abnormalities...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
1938
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2133562/ https://www.ncbi.nlm.nih.gov/pubmed/19870713 |
| _version_ | 1782142698310860800 |
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| author | Wilcox, Herbert B. Andrus, E. Cowles |
| author_facet | Wilcox, Herbert B. Andrus, E. Cowles |
| author_sort | Wilcox, Herbert B. |
| collection | PubMed |
| description | The isolated hearts of guinea pigs sensitized to horse serum have been shown to react characteristically upon exposure to small amounts of antigen. The cardiac rate is temporarily accelerated and transient alterations in amplitude of contraction are to be observed. Electrocardiographic abnormalities, previously recorded by remote leads during anaphylactic shock in the intact animal, have been recorded by direct leads from the isolated perfused hearts of sensitized animals during this reaction. An additional effect of anaphylaxis in the isolated heart of the guinea pig is reported: a striking reduction in the rate of flow through the coronary vessels. The anaphylactic reaction of the isolated heart of the guinea pig has been compared with the action of histamine upon the same preparation and the effect of atropine upon each has been observed. The implications of certain quantitative differences in the influence of atropine upon these reactions are discussed. |
| format | Text |
| id | pubmed-2133562 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 1938 |
| publisher | The Rockefeller University Press |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-21335622008-04-18 ANAPHYLAXIS IN THE ISOLATED HEART Wilcox, Herbert B. Andrus, E. Cowles J Exp Med Article The isolated hearts of guinea pigs sensitized to horse serum have been shown to react characteristically upon exposure to small amounts of antigen. The cardiac rate is temporarily accelerated and transient alterations in amplitude of contraction are to be observed. Electrocardiographic abnormalities, previously recorded by remote leads during anaphylactic shock in the intact animal, have been recorded by direct leads from the isolated perfused hearts of sensitized animals during this reaction. An additional effect of anaphylaxis in the isolated heart of the guinea pig is reported: a striking reduction in the rate of flow through the coronary vessels. The anaphylactic reaction of the isolated heart of the guinea pig has been compared with the action of histamine upon the same preparation and the effect of atropine upon each has been observed. The implications of certain quantitative differences in the influence of atropine upon these reactions are discussed. The Rockefeller University Press 1938-01-31 /pmc/articles/PMC2133562/ /pubmed/19870713 Text en Copyright © Copyright, 1938, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
| spellingShingle | Article Wilcox, Herbert B. Andrus, E. Cowles ANAPHYLAXIS IN THE ISOLATED HEART |
| title | ANAPHYLAXIS IN THE ISOLATED HEART |
| title_full | ANAPHYLAXIS IN THE ISOLATED HEART |
| title_fullStr | ANAPHYLAXIS IN THE ISOLATED HEART |
| title_full_unstemmed | ANAPHYLAXIS IN THE ISOLATED HEART |
| title_short | ANAPHYLAXIS IN THE ISOLATED HEART |
| title_sort | anaphylaxis in the isolated heart |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2133562/ https://www.ncbi.nlm.nih.gov/pubmed/19870713 |
| work_keys_str_mv | AT wilcoxherbertb anaphylaxisintheisolatedheart AT andrusecowles anaphylaxisintheisolatedheart |