A STABLE HEMOLYSIN-LEUCOCIDIN AND ITS CRYSTAL-LINE DERIVATIVE ISOLATED FROM BETA HEMOLYTIC STREPTOCOCCI

1. A chemically pure hemolysin-leucocidin has been isolated from β hemolytic streptococci, but not from other species of bacteria studied. 2. It does not give rise to antibodies, but precipitates immune sera against hemolytic streptococci, and is therefore a hapten. 3. A highly purified sample of S....

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Detalles Bibliográficos
Autores principales: Czarnetzky, E. J., Morgan, Isabel M., Mudd, Stuart
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1938
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2133603/
https://www.ncbi.nlm.nih.gov/pubmed/19870745
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author Czarnetzky, E. J.
Morgan, Isabel M.
Mudd, Stuart
author_facet Czarnetzky, E. J.
Morgan, Isabel M.
Mudd, Stuart
author_sort Czarnetzky, E. J.
collection PubMed
description 1. A chemically pure hemolysin-leucocidin has been isolated from β hemolytic streptococci, but not from other species of bacteria studied. 2. It does not give rise to antibodies, but precipitates immune sera against hemolytic streptococci, and is therefore a hapten. 3. A highly purified sample of S. H. up to a dilution of 1:128,000 hemolyzes red blood cells. Its hemolytic activity is not specifically neutralized by antiserum versus β hemolytic streptococci. It is leucocidic in that it inhibits the reduction of methylene blue by leucocytes. 4. The hemolysin-leucocidin is stable to oxygen, to heat and to moderate changes in hydrogen ion concentration. Its chemical structure has been determined in part. Its molecular weight is 2260. 5. A crystalline derivative has been isolated as the sodium salt from the hemolysin-leucocidin. As the free acid it has a molecular weight of 720. Its hemolytic and leucocidic activity parallels that of S. H., although it is not serologically active. It possesses a high degree of toxicity for mice and rabbits.
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spelling pubmed-21336032008-04-18 A STABLE HEMOLYSIN-LEUCOCIDIN AND ITS CRYSTAL-LINE DERIVATIVE ISOLATED FROM BETA HEMOLYTIC STREPTOCOCCI Czarnetzky, E. J. Morgan, Isabel M. Mudd, Stuart J Exp Med Article 1. A chemically pure hemolysin-leucocidin has been isolated from β hemolytic streptococci, but not from other species of bacteria studied. 2. It does not give rise to antibodies, but precipitates immune sera against hemolytic streptococci, and is therefore a hapten. 3. A highly purified sample of S. H. up to a dilution of 1:128,000 hemolyzes red blood cells. Its hemolytic activity is not specifically neutralized by antiserum versus β hemolytic streptococci. It is leucocidic in that it inhibits the reduction of methylene blue by leucocytes. 4. The hemolysin-leucocidin is stable to oxygen, to heat and to moderate changes in hydrogen ion concentration. Its chemical structure has been determined in part. Its molecular weight is 2260. 5. A crystalline derivative has been isolated as the sodium salt from the hemolysin-leucocidin. As the free acid it has a molecular weight of 720. Its hemolytic and leucocidic activity parallels that of S. H., although it is not serologically active. It possesses a high degree of toxicity for mice and rabbits. The Rockefeller University Press 1938-03-31 /pmc/articles/PMC2133603/ /pubmed/19870745 Text en Copyright © Copyright, 1938, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Czarnetzky, E. J.
Morgan, Isabel M.
Mudd, Stuart
A STABLE HEMOLYSIN-LEUCOCIDIN AND ITS CRYSTAL-LINE DERIVATIVE ISOLATED FROM BETA HEMOLYTIC STREPTOCOCCI
title A STABLE HEMOLYSIN-LEUCOCIDIN AND ITS CRYSTAL-LINE DERIVATIVE ISOLATED FROM BETA HEMOLYTIC STREPTOCOCCI
title_full A STABLE HEMOLYSIN-LEUCOCIDIN AND ITS CRYSTAL-LINE DERIVATIVE ISOLATED FROM BETA HEMOLYTIC STREPTOCOCCI
title_fullStr A STABLE HEMOLYSIN-LEUCOCIDIN AND ITS CRYSTAL-LINE DERIVATIVE ISOLATED FROM BETA HEMOLYTIC STREPTOCOCCI
title_full_unstemmed A STABLE HEMOLYSIN-LEUCOCIDIN AND ITS CRYSTAL-LINE DERIVATIVE ISOLATED FROM BETA HEMOLYTIC STREPTOCOCCI
title_short A STABLE HEMOLYSIN-LEUCOCIDIN AND ITS CRYSTAL-LINE DERIVATIVE ISOLATED FROM BETA HEMOLYTIC STREPTOCOCCI
title_sort stable hemolysin-leucocidin and its crystal-line derivative isolated from beta hemolytic streptococci
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2133603/
https://www.ncbi.nlm.nih.gov/pubmed/19870745
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