THE SOLUBLE MALARIAL ANTIGEN IN THE SERUM OF MONKEYS INFECTED WITH PLASMODIUM KNOWLESI

A soluble malarial antigen which fixes complement with immune serum is found in the serum of monkeys infected with Plasmodium knowlesi. The amount of antigen in the serum is related to the parasite count during the acute phase of the infection. The antigen is not excreted in the urine. Intravenous i...

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Detalles Bibliográficos
Autor principal: Eaton, Monroe D.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1939
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2133650/
https://www.ncbi.nlm.nih.gov/pubmed/19870861
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author Eaton, Monroe D.
author_facet Eaton, Monroe D.
author_sort Eaton, Monroe D.
collection PubMed
description A soluble malarial antigen which fixes complement with immune serum is found in the serum of monkeys infected with Plasmodium knowlesi. The amount of antigen in the serum is related to the parasite count during the acute phase of the infection. The antigen is not excreted in the urine. Intravenous injection into normal monkeys of serum containing the antigen stimulates the production of specific complement-fixing antibodies which react with antigens extracted from parasitized cells, as well as with the antigen present in serum obtained during the acute phase of infection. Monkeys immunized with serum antigen apparently possess very little or no immunity to infection. The soluble malarial antigen is labile to acids and alkalies, is not destroyed by a temperature of 56°C., and is precipitated, for the most part, in the albumin fraction of the serum by ammonium sulfate.
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spelling pubmed-21336502008-04-18 THE SOLUBLE MALARIAL ANTIGEN IN THE SERUM OF MONKEYS INFECTED WITH PLASMODIUM KNOWLESI Eaton, Monroe D. J Exp Med Article A soluble malarial antigen which fixes complement with immune serum is found in the serum of monkeys infected with Plasmodium knowlesi. The amount of antigen in the serum is related to the parasite count during the acute phase of the infection. The antigen is not excreted in the urine. Intravenous injection into normal monkeys of serum containing the antigen stimulates the production of specific complement-fixing antibodies which react with antigens extracted from parasitized cells, as well as with the antigen present in serum obtained during the acute phase of infection. Monkeys immunized with serum antigen apparently possess very little or no immunity to infection. The soluble malarial antigen is labile to acids and alkalies, is not destroyed by a temperature of 56°C., and is precipitated, for the most part, in the albumin fraction of the serum by ammonium sulfate. The Rockefeller University Press 1939-03-31 /pmc/articles/PMC2133650/ /pubmed/19870861 Text en Copyright © Copyright, 1939, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Eaton, Monroe D.
THE SOLUBLE MALARIAL ANTIGEN IN THE SERUM OF MONKEYS INFECTED WITH PLASMODIUM KNOWLESI
title THE SOLUBLE MALARIAL ANTIGEN IN THE SERUM OF MONKEYS INFECTED WITH PLASMODIUM KNOWLESI
title_full THE SOLUBLE MALARIAL ANTIGEN IN THE SERUM OF MONKEYS INFECTED WITH PLASMODIUM KNOWLESI
title_fullStr THE SOLUBLE MALARIAL ANTIGEN IN THE SERUM OF MONKEYS INFECTED WITH PLASMODIUM KNOWLESI
title_full_unstemmed THE SOLUBLE MALARIAL ANTIGEN IN THE SERUM OF MONKEYS INFECTED WITH PLASMODIUM KNOWLESI
title_short THE SOLUBLE MALARIAL ANTIGEN IN THE SERUM OF MONKEYS INFECTED WITH PLASMODIUM KNOWLESI
title_sort soluble malarial antigen in the serum of monkeys infected with plasmodium knowlesi
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2133650/
https://www.ncbi.nlm.nih.gov/pubmed/19870861
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AT eatonmonroed solublemalarialantigenintheserumofmonkeysinfectedwithplasmodiumknowlesi

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