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IMMUNOLOGICAL REACTIONS WITH A VIRUS CAUSING PAPILLOMAS IN RABBITS : II. PROPERTIES OF THE COMPLEMENT-BINDING ANTIGEN PRESENT IN EXTRACTS OF THE GROWTHS: ITS RELATION TO THE VIRUS
The antigen that binds complement in the presence of sera neutralizing the Shope papilloma virus can be readily extracted from papillomas yielding infectious virus, but not from the normal skin of rabbits bearing the growths. The virus and the complement-binding antigen appear to have the same parti...
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
1938
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2133700/ https://www.ncbi.nlm.nih.gov/pubmed/19870813 |
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author | Kidd, John G. |
author_facet | Kidd, John G. |
author_sort | Kidd, John G. |
collection | PubMed |
description | The antigen that binds complement in the presence of sera neutralizing the Shope papilloma virus can be readily extracted from papillomas yielding infectious virus, but not from the normal skin of rabbits bearing the growths. The virus and the complement-binding antigen appear to have the same particle size, as determined by filtration, and they are thrown down together in the centrifuge. They are destroyed by the same amounts of heating and, in general, by the same changes in pH. It is possible, nevertheless, by irradiation with ultraviolet light, or by treatment with weak alkali, to render papilloma extracts non-pathogenic without diminishing their capacity to bind complement when mixed with immune serum. |
format | Text |
id | pubmed-2133700 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1938 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21337002008-04-18 IMMUNOLOGICAL REACTIONS WITH A VIRUS CAUSING PAPILLOMAS IN RABBITS : II. PROPERTIES OF THE COMPLEMENT-BINDING ANTIGEN PRESENT IN EXTRACTS OF THE GROWTHS: ITS RELATION TO THE VIRUS Kidd, John G. J Exp Med Article The antigen that binds complement in the presence of sera neutralizing the Shope papilloma virus can be readily extracted from papillomas yielding infectious virus, but not from the normal skin of rabbits bearing the growths. The virus and the complement-binding antigen appear to have the same particle size, as determined by filtration, and they are thrown down together in the centrifuge. They are destroyed by the same amounts of heating and, in general, by the same changes in pH. It is possible, nevertheless, by irradiation with ultraviolet light, or by treatment with weak alkali, to render papilloma extracts non-pathogenic without diminishing their capacity to bind complement when mixed with immune serum. The Rockefeller University Press 1938-10-31 /pmc/articles/PMC2133700/ /pubmed/19870813 Text en Copyright © Copyright, 1938, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Kidd, John G. IMMUNOLOGICAL REACTIONS WITH A VIRUS CAUSING PAPILLOMAS IN RABBITS : II. PROPERTIES OF THE COMPLEMENT-BINDING ANTIGEN PRESENT IN EXTRACTS OF THE GROWTHS: ITS RELATION TO THE VIRUS |
title | IMMUNOLOGICAL REACTIONS WITH A VIRUS CAUSING PAPILLOMAS IN RABBITS : II. PROPERTIES OF THE COMPLEMENT-BINDING ANTIGEN PRESENT IN EXTRACTS OF THE GROWTHS: ITS RELATION TO THE VIRUS |
title_full | IMMUNOLOGICAL REACTIONS WITH A VIRUS CAUSING PAPILLOMAS IN RABBITS : II. PROPERTIES OF THE COMPLEMENT-BINDING ANTIGEN PRESENT IN EXTRACTS OF THE GROWTHS: ITS RELATION TO THE VIRUS |
title_fullStr | IMMUNOLOGICAL REACTIONS WITH A VIRUS CAUSING PAPILLOMAS IN RABBITS : II. PROPERTIES OF THE COMPLEMENT-BINDING ANTIGEN PRESENT IN EXTRACTS OF THE GROWTHS: ITS RELATION TO THE VIRUS |
title_full_unstemmed | IMMUNOLOGICAL REACTIONS WITH A VIRUS CAUSING PAPILLOMAS IN RABBITS : II. PROPERTIES OF THE COMPLEMENT-BINDING ANTIGEN PRESENT IN EXTRACTS OF THE GROWTHS: ITS RELATION TO THE VIRUS |
title_short | IMMUNOLOGICAL REACTIONS WITH A VIRUS CAUSING PAPILLOMAS IN RABBITS : II. PROPERTIES OF THE COMPLEMENT-BINDING ANTIGEN PRESENT IN EXTRACTS OF THE GROWTHS: ITS RELATION TO THE VIRUS |
title_sort | immunological reactions with a virus causing papillomas in rabbits : ii. properties of the complement-binding antigen present in extracts of the growths: its relation to the virus |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2133700/ https://www.ncbi.nlm.nih.gov/pubmed/19870813 |
work_keys_str_mv | AT kiddjohng immunologicalreactionswithaviruscausingpapillomasinrabbitsiipropertiesofthecomplementbindingantigenpresentinextractsofthegrowthsitsrelationtothevirus |