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TUBERCULAR ALLERGY WITHOUT INFECTION

1. Guinea pigs can be rendered hypersensitive to tuberculo-protein by small, repeated, intradermal injections of active tuberculo-protein. 2. The addition of tuberculo-phosphatide to the protein speeds up the process of sensitization and enhances it so that the reactions become indurated and necroti...

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Autores principales: Sabin, Florence R., Joyner, Austin L.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1938
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2133704/
https://www.ncbi.nlm.nih.gov/pubmed/19870809
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author Sabin, Florence R.
Joyner, Austin L.
author_facet Sabin, Florence R.
Joyner, Austin L.
author_sort Sabin, Florence R.
collection PubMed
description 1. Guinea pigs can be rendered hypersensitive to tuberculo-protein by small, repeated, intradermal injections of active tuberculo-protein. 2. The addition of tuberculo-phosphatide to the protein speeds up the process of sensitization and enhances it so that the reactions become indurated and necrotic, closely simulating those of the disease. 3. Active tuberculo-proteins induce a new formation of monocytes and some epithelioid cells. The addition of phosphatide to the protein brings about a massive formation of epithelioid cells. 4. With the increased cellular reaction to the mixed injections may be correlated the increase in the speed and intensity of the sensitization. 5. The intradermal route is the best for these sensitizations, probably because it provides the greatest dose per cell of the sensitizing agent. 6. The degree of sensitization artificially obtainable by the synergistic action of tuberculo-phosphatide and tuberculo-protein is quite comparable to the degree of sensitization naturally occurring in tuberculous animals; moreover, this degree of sensitization may be induced with amounts of the materials from the bacilli which could conceivably be present in the tissues of an infected host.
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spelling pubmed-21337042008-04-18 TUBERCULAR ALLERGY WITHOUT INFECTION Sabin, Florence R. Joyner, Austin L. J Exp Med Article 1. Guinea pigs can be rendered hypersensitive to tuberculo-protein by small, repeated, intradermal injections of active tuberculo-protein. 2. The addition of tuberculo-phosphatide to the protein speeds up the process of sensitization and enhances it so that the reactions become indurated and necrotic, closely simulating those of the disease. 3. Active tuberculo-proteins induce a new formation of monocytes and some epithelioid cells. The addition of phosphatide to the protein brings about a massive formation of epithelioid cells. 4. With the increased cellular reaction to the mixed injections may be correlated the increase in the speed and intensity of the sensitization. 5. The intradermal route is the best for these sensitizations, probably because it provides the greatest dose per cell of the sensitizing agent. 6. The degree of sensitization artificially obtainable by the synergistic action of tuberculo-phosphatide and tuberculo-protein is quite comparable to the degree of sensitization naturally occurring in tuberculous animals; moreover, this degree of sensitization may be induced with amounts of the materials from the bacilli which could conceivably be present in the tissues of an infected host. The Rockefeller University Press 1938-10-31 /pmc/articles/PMC2133704/ /pubmed/19870809 Text en Copyright © Copyright, 1938, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Sabin, Florence R.
Joyner, Austin L.
TUBERCULAR ALLERGY WITHOUT INFECTION
title TUBERCULAR ALLERGY WITHOUT INFECTION
title_full TUBERCULAR ALLERGY WITHOUT INFECTION
title_fullStr TUBERCULAR ALLERGY WITHOUT INFECTION
title_full_unstemmed TUBERCULAR ALLERGY WITHOUT INFECTION
title_short TUBERCULAR ALLERGY WITHOUT INFECTION
title_sort tubercular allergy without infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2133704/
https://www.ncbi.nlm.nih.gov/pubmed/19870809
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