INFECTIOUS MYXOMATOSIS OF RABBITS : STUDIES OF A SOLUBLE ANTIGEN ASSOCIATED WITH THE DISEASE

The soluble antigen of myxoma is a heat-labile protein which has an isoelectric point near pH 4.5 and is precipitated from half saturated solutions of ammonium sulfate. It can be partially purified by methods of differential precipitation based on variations in the pH and electrolyte concentration....

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Detalles Bibliográficos
Autores principales: Rivers, Thomas M., Ward, S. M., Smadel, Joseph E.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1939
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2133719/
https://www.ncbi.nlm.nih.gov/pubmed/19870836
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author Rivers, Thomas M.
Ward, S. M.
Smadel, Joseph E.
author_facet Rivers, Thomas M.
Ward, S. M.
Smadel, Joseph E.
author_sort Rivers, Thomas M.
collection PubMed
description The soluble antigen of myxoma is a heat-labile protein which has an isoelectric point near pH 4.5 and is precipitated from half saturated solutions of ammonium sulfate. It can be partially purified by methods of differential precipitation based on variations in the pH and electrolyte concentration. Rabbits receiving the labile, soluble substance of myxoma develop homologous precipitins and their serum agglutinates elementary bodies of myxoma, provided the dermal pulp from which the bodies are obtained contains the soluble substance; neutralizing antibodies do not appear, however, and the animals are not resistant to infection with the virus of myxoma. Elementary bodies of myxoma appear to have a heat-stable agglutinogen that operates when brought in contact with serum from animals recovered from myxoma, but little, if at all, when in contact with anti-soluble substance serum.
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spelling pubmed-21337192008-04-18 INFECTIOUS MYXOMATOSIS OF RABBITS : STUDIES OF A SOLUBLE ANTIGEN ASSOCIATED WITH THE DISEASE Rivers, Thomas M. Ward, S. M. Smadel, Joseph E. J Exp Med Article The soluble antigen of myxoma is a heat-labile protein which has an isoelectric point near pH 4.5 and is precipitated from half saturated solutions of ammonium sulfate. It can be partially purified by methods of differential precipitation based on variations in the pH and electrolyte concentration. Rabbits receiving the labile, soluble substance of myxoma develop homologous precipitins and their serum agglutinates elementary bodies of myxoma, provided the dermal pulp from which the bodies are obtained contains the soluble substance; neutralizing antibodies do not appear, however, and the animals are not resistant to infection with the virus of myxoma. Elementary bodies of myxoma appear to have a heat-stable agglutinogen that operates when brought in contact with serum from animals recovered from myxoma, but little, if at all, when in contact with anti-soluble substance serum. The Rockefeller University Press 1939-01-01 /pmc/articles/PMC2133719/ /pubmed/19870836 Text en Copyright © Copyright, 1939, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Rivers, Thomas M.
Ward, S. M.
Smadel, Joseph E.
INFECTIOUS MYXOMATOSIS OF RABBITS : STUDIES OF A SOLUBLE ANTIGEN ASSOCIATED WITH THE DISEASE
title INFECTIOUS MYXOMATOSIS OF RABBITS : STUDIES OF A SOLUBLE ANTIGEN ASSOCIATED WITH THE DISEASE
title_full INFECTIOUS MYXOMATOSIS OF RABBITS : STUDIES OF A SOLUBLE ANTIGEN ASSOCIATED WITH THE DISEASE
title_fullStr INFECTIOUS MYXOMATOSIS OF RABBITS : STUDIES OF A SOLUBLE ANTIGEN ASSOCIATED WITH THE DISEASE
title_full_unstemmed INFECTIOUS MYXOMATOSIS OF RABBITS : STUDIES OF A SOLUBLE ANTIGEN ASSOCIATED WITH THE DISEASE
title_short INFECTIOUS MYXOMATOSIS OF RABBITS : STUDIES OF A SOLUBLE ANTIGEN ASSOCIATED WITH THE DISEASE
title_sort infectious myxomatosis of rabbits : studies of a soluble antigen associated with the disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2133719/
https://www.ncbi.nlm.nih.gov/pubmed/19870836
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AT wardsm infectiousmyxomatosisofrabbitsstudiesofasolubleantigenassociatedwiththedisease
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