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STUDIES ON EASTERN EQUINE ENCEPHALOMYELITIS : II. PATHOGENESIS OF THE DISEASE IN THE GUINEA PIG
After inoculation with equine encephalomyelitis virus by various routes, guinea pigs were sacrificed at early stages, before symptoms were apparent. The brains were studied histologically, with serial sections; all lesions were noted, and subjected to topographical analysis. Nine cases are presented...
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
1939
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2133754/ https://www.ncbi.nlm.nih.gov/pubmed/19870870 |
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author | King, Lester S. |
author_facet | King, Lester S. |
author_sort | King, Lester S. |
collection | PubMed |
description | After inoculation with equine encephalomyelitis virus by various routes, guinea pigs were sacrificed at early stages, before symptoms were apparent. The brains were studied histologically, with serial sections; all lesions were noted, and subjected to topographical analysis. Nine cases are presented in detail. With any given mode of inoculation the distribution of lesions varied very widely from one instance to another. In some cases, affected regions bore a striking and definite anatomical relationship to each other. These distributions can be explained only by the assumption that the anatomical pathways played some rôle in the spread of the virus. In other instances lesions were present in areas, the anatomical connections of which were entirely normal. Attention is called to the frequency of lesions in the neocortex, with intact subcortical centers. Such distribution is held to render nerve spread extremely improbable. The only satisfactory explanation of such random distributions is by direct passage of virus from the blood stream into the brain tissue. There is no histological difference between lesions which result from blood spread and those resulting from nerve spread. |
format | Text |
id | pubmed-2133754 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1939 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21337542008-04-18 STUDIES ON EASTERN EQUINE ENCEPHALOMYELITIS : II. PATHOGENESIS OF THE DISEASE IN THE GUINEA PIG King, Lester S. J Exp Med Article After inoculation with equine encephalomyelitis virus by various routes, guinea pigs were sacrificed at early stages, before symptoms were apparent. The brains were studied histologically, with serial sections; all lesions were noted, and subjected to topographical analysis. Nine cases are presented in detail. With any given mode of inoculation the distribution of lesions varied very widely from one instance to another. In some cases, affected regions bore a striking and definite anatomical relationship to each other. These distributions can be explained only by the assumption that the anatomical pathways played some rôle in the spread of the virus. In other instances lesions were present in areas, the anatomical connections of which were entirely normal. Attention is called to the frequency of lesions in the neocortex, with intact subcortical centers. Such distribution is held to render nerve spread extremely improbable. The only satisfactory explanation of such random distributions is by direct passage of virus from the blood stream into the brain tissue. There is no histological difference between lesions which result from blood spread and those resulting from nerve spread. The Rockefeller University Press 1939-04-30 /pmc/articles/PMC2133754/ /pubmed/19870870 Text en Copyright © Copyright, 1939, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article King, Lester S. STUDIES ON EASTERN EQUINE ENCEPHALOMYELITIS : II. PATHOGENESIS OF THE DISEASE IN THE GUINEA PIG |
title | STUDIES ON EASTERN EQUINE ENCEPHALOMYELITIS : II. PATHOGENESIS OF THE DISEASE IN THE GUINEA PIG |
title_full | STUDIES ON EASTERN EQUINE ENCEPHALOMYELITIS : II. PATHOGENESIS OF THE DISEASE IN THE GUINEA PIG |
title_fullStr | STUDIES ON EASTERN EQUINE ENCEPHALOMYELITIS : II. PATHOGENESIS OF THE DISEASE IN THE GUINEA PIG |
title_full_unstemmed | STUDIES ON EASTERN EQUINE ENCEPHALOMYELITIS : II. PATHOGENESIS OF THE DISEASE IN THE GUINEA PIG |
title_short | STUDIES ON EASTERN EQUINE ENCEPHALOMYELITIS : II. PATHOGENESIS OF THE DISEASE IN THE GUINEA PIG |
title_sort | studies on eastern equine encephalomyelitis : ii. pathogenesis of the disease in the guinea pig |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2133754/ https://www.ncbi.nlm.nih.gov/pubmed/19870870 |
work_keys_str_mv | AT kinglesters studiesoneasternequineencephalomyelitisiipathogenesisofthediseaseintheguineapig |