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SEROLOGICAL STUDIES OF SWINE INFLUENZA VIRUSES

1. Cross-neutralization tests with sera from swine recovered from infection with swine influenza indicated the serological identity of 7 strains of swine influenza virus obtained from different sources. 2. Cross-neutralization tests with sera from rabbits, immunized to swine influenza virus, exposed...

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Autor principal: Shope, Richard E.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1939
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2133761/
https://www.ncbi.nlm.nih.gov/pubmed/19870881
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author Shope, Richard E.
author_facet Shope, Richard E.
author_sort Shope, Richard E.
collection PubMed
description 1. Cross-neutralization tests with sera from swine recovered from infection with swine influenza indicated the serological identity of 7 strains of swine influenza virus obtained from different sources. 2. Cross-neutralization tests with sera from rabbits, immunized to swine influenza virus, exposed serological differences among the same 7 swine influenza virus strains. Two strains appeared to be serologically similar and were characterized by the ability to produce effective homologous virus-neutralizing sera which were, however, poor or ineffective against the heterologous virus strains. Two other strains were also serologically similar but produced antibodies effective not only against themselves, but against all heterologous strains as well. The remaining 3 strains were intermediate in their ability to produce heterologous virus-neutralizing antibodies. 3. The human influenza viruses included, especially strains WS and Oakham, were most effectively differentiated serologically from the swine influenza viruses by rabbit antisera. 4. The suggestion is advanced that swine antisera express the antigenic composition of the swine influenza viruses, while rabbit antisera reflect either their antigenic arrangement or the arrangement of the components responsible for their mouse pathogenicity. On this interpretation the 7 strains of swine influenza virus studied would be considered to have similar antigenic compositions but differing antigenic structures. 5. The serological differences among strains of the swine influenza virus, detectible by rabbit antisera, are probably of no practical significance so far as the natural disease, swine influenza, is concerned.
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spelling pubmed-21337612008-04-18 SEROLOGICAL STUDIES OF SWINE INFLUENZA VIRUSES Shope, Richard E. J Exp Med Article 1. Cross-neutralization tests with sera from swine recovered from infection with swine influenza indicated the serological identity of 7 strains of swine influenza virus obtained from different sources. 2. Cross-neutralization tests with sera from rabbits, immunized to swine influenza virus, exposed serological differences among the same 7 swine influenza virus strains. Two strains appeared to be serologically similar and were characterized by the ability to produce effective homologous virus-neutralizing sera which were, however, poor or ineffective against the heterologous virus strains. Two other strains were also serologically similar but produced antibodies effective not only against themselves, but against all heterologous strains as well. The remaining 3 strains were intermediate in their ability to produce heterologous virus-neutralizing antibodies. 3. The human influenza viruses included, especially strains WS and Oakham, were most effectively differentiated serologically from the swine influenza viruses by rabbit antisera. 4. The suggestion is advanced that swine antisera express the antigenic composition of the swine influenza viruses, while rabbit antisera reflect either their antigenic arrangement or the arrangement of the components responsible for their mouse pathogenicity. On this interpretation the 7 strains of swine influenza virus studied would be considered to have similar antigenic compositions but differing antigenic structures. 5. The serological differences among strains of the swine influenza virus, detectible by rabbit antisera, are probably of no practical significance so far as the natural disease, swine influenza, is concerned. The Rockefeller University Press 1939-05-31 /pmc/articles/PMC2133761/ /pubmed/19870881 Text en Copyright © Copyright, 1939, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Shope, Richard E.
SEROLOGICAL STUDIES OF SWINE INFLUENZA VIRUSES
title SEROLOGICAL STUDIES OF SWINE INFLUENZA VIRUSES
title_full SEROLOGICAL STUDIES OF SWINE INFLUENZA VIRUSES
title_fullStr SEROLOGICAL STUDIES OF SWINE INFLUENZA VIRUSES
title_full_unstemmed SEROLOGICAL STUDIES OF SWINE INFLUENZA VIRUSES
title_short SEROLOGICAL STUDIES OF SWINE INFLUENZA VIRUSES
title_sort serological studies of swine influenza viruses
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2133761/
https://www.ncbi.nlm.nih.gov/pubmed/19870881
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