IMMUNE RESPONSE OF RABBITS TO INJECTION OF PLASMODIUM KNOWLESI

Specific complement-fixing antibodies are produced in the serum of rabbits in response to injections of living or dead Plasmodium knowlesi. Sera from rabbits receiving injections of either parasitized or normal monkey erythrocytes are parasiticidal in vitro for P. knowlesi. Because absorption of par...

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Detalles Bibliográficos
Autores principales: Eaton, Monroe D., Coggeshall, L. T.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1939
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2133792/
https://www.ncbi.nlm.nih.gov/pubmed/19870895
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author Eaton, Monroe D.
Coggeshall, L. T.
author_facet Eaton, Monroe D.
Coggeshall, L. T.
author_sort Eaton, Monroe D.
collection PubMed
description Specific complement-fixing antibodies are produced in the serum of rabbits in response to injections of living or dead Plasmodium knowlesi. Sera from rabbits receiving injections of either parasitized or normal monkey erythrocytes are parasiticidal in vitro for P. knowlesi. Because absorption of parasiticidal rabbit sera with normal monkey erythrocytes abolishes the parasiticidal effect, it is concluded that the effect is largely due to an antibody to the red cells. Normal rabbit serum is not parasiticidal. Experiments on passive protection in monkey malaria with serum from rabbits which have received intraperitoneal injections of living or dead P. knowlesi yield no conclusive evidence that protective antibodies are formed.
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spelling pubmed-21337922008-04-18 IMMUNE RESPONSE OF RABBITS TO INJECTION OF PLASMODIUM KNOWLESI Eaton, Monroe D. Coggeshall, L. T. J Exp Med Article Specific complement-fixing antibodies are produced in the serum of rabbits in response to injections of living or dead Plasmodium knowlesi. Sera from rabbits receiving injections of either parasitized or normal monkey erythrocytes are parasiticidal in vitro for P. knowlesi. Because absorption of parasiticidal rabbit sera with normal monkey erythrocytes abolishes the parasiticidal effect, it is concluded that the effect is largely due to an antibody to the red cells. Normal rabbit serum is not parasiticidal. Experiments on passive protection in monkey malaria with serum from rabbits which have received intraperitoneal injections of living or dead P. knowlesi yield no conclusive evidence that protective antibodies are formed. The Rockefeller University Press 1939-07-31 /pmc/articles/PMC2133792/ /pubmed/19870895 Text en Copyright © Copyright, 1939, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Eaton, Monroe D.
Coggeshall, L. T.
IMMUNE RESPONSE OF RABBITS TO INJECTION OF PLASMODIUM KNOWLESI
title IMMUNE RESPONSE OF RABBITS TO INJECTION OF PLASMODIUM KNOWLESI
title_full IMMUNE RESPONSE OF RABBITS TO INJECTION OF PLASMODIUM KNOWLESI
title_fullStr IMMUNE RESPONSE OF RABBITS TO INJECTION OF PLASMODIUM KNOWLESI
title_full_unstemmed IMMUNE RESPONSE OF RABBITS TO INJECTION OF PLASMODIUM KNOWLESI
title_short IMMUNE RESPONSE OF RABBITS TO INJECTION OF PLASMODIUM KNOWLESI
title_sort immune response of rabbits to injection of plasmodium knowlesi
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2133792/
https://www.ncbi.nlm.nih.gov/pubmed/19870895
work_keys_str_mv AT eatonmonroed immuneresponseofrabbitstoinjectionofplasmodiumknowlesi
AT coggeshalllt immuneresponseofrabbitstoinjectionofplasmodiumknowlesi

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