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A FURTHER CONTRIBUTION TO VITAMIN C THERAPY IN EXPERIMENTAL POLIOMYELITIS

1. Multiple paralytic doses of poliomyelitis virus (RMV strain), when brought together with small amounts of synthetic ascorbic acid in vitro, are rendered non-infectious as determined by intracerebral injection of such mixtures into rhesus monkeys. 2. Vitamin C administration to monkeys infected in...

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Detalles Bibliográficos
Autor principal: Jungeblut, Claus W.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1939
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2133810/
https://www.ncbi.nlm.nih.gov/pubmed/19870912
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author Jungeblut, Claus W.
author_facet Jungeblut, Claus W.
author_sort Jungeblut, Claus W.
collection PubMed
description 1. Multiple paralytic doses of poliomyelitis virus (RMV strain), when brought together with small amounts of synthetic ascorbic acid in vitro, are rendered non-infectious as determined by intracerebral injection of such mixtures into rhesus monkeys. 2. Vitamin C administration to monkeys infected intranasally with the RMV strain produces results which differ in accordance with the technique employed for nasal instillation. With an infection of maximum severity, induced by flooding the nasal portal of entry with large amounts of virus, vitamin C administration fails to exert any demonstrable influence on the course of the disease. With a less forceful method of droplet instillation, the picture of the disease in control animals becomes so variable that the results cannot be easily interpreted; but the available data suggest that vitamin C treatment may be a factor in converting abortive attacks into an altogether non-paralytic infection. 3. The administration of synthetic vitamin C to monkeys infected intracerebrally with small doses of the RMV strain gives results comparable to those previously obtained with this substance in monkeys infected intracerebrally with the Aycock strain of poliomyelitis virus. 4. The implications of the findings are discussed.
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spelling pubmed-21338102008-04-18 A FURTHER CONTRIBUTION TO VITAMIN C THERAPY IN EXPERIMENTAL POLIOMYELITIS Jungeblut, Claus W. J Exp Med Article 1. Multiple paralytic doses of poliomyelitis virus (RMV strain), when brought together with small amounts of synthetic ascorbic acid in vitro, are rendered non-infectious as determined by intracerebral injection of such mixtures into rhesus monkeys. 2. Vitamin C administration to monkeys infected intranasally with the RMV strain produces results which differ in accordance with the technique employed for nasal instillation. With an infection of maximum severity, induced by flooding the nasal portal of entry with large amounts of virus, vitamin C administration fails to exert any demonstrable influence on the course of the disease. With a less forceful method of droplet instillation, the picture of the disease in control animals becomes so variable that the results cannot be easily interpreted; but the available data suggest that vitamin C treatment may be a factor in converting abortive attacks into an altogether non-paralytic infection. 3. The administration of synthetic vitamin C to monkeys infected intracerebrally with small doses of the RMV strain gives results comparable to those previously obtained with this substance in monkeys infected intracerebrally with the Aycock strain of poliomyelitis virus. 4. The implications of the findings are discussed. The Rockefeller University Press 1939-08-31 /pmc/articles/PMC2133810/ /pubmed/19870912 Text en Copyright © Copyright, 1939, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Jungeblut, Claus W.
A FURTHER CONTRIBUTION TO VITAMIN C THERAPY IN EXPERIMENTAL POLIOMYELITIS
title A FURTHER CONTRIBUTION TO VITAMIN C THERAPY IN EXPERIMENTAL POLIOMYELITIS
title_full A FURTHER CONTRIBUTION TO VITAMIN C THERAPY IN EXPERIMENTAL POLIOMYELITIS
title_fullStr A FURTHER CONTRIBUTION TO VITAMIN C THERAPY IN EXPERIMENTAL POLIOMYELITIS
title_full_unstemmed A FURTHER CONTRIBUTION TO VITAMIN C THERAPY IN EXPERIMENTAL POLIOMYELITIS
title_short A FURTHER CONTRIBUTION TO VITAMIN C THERAPY IN EXPERIMENTAL POLIOMYELITIS
title_sort further contribution to vitamin c therapy in experimental poliomyelitis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2133810/
https://www.ncbi.nlm.nih.gov/pubmed/19870912
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