STUDIES ON A BACTERICIDAL AGENT EXTRACTED FROM A SOIL BACILLUS : III. PREPARATION AND ACTIVITY OF A PROTEIN-FREE FRACTION

A cell-free extract of cultures of an unidentified soil bacillus, which exerts a bactericidal effect on Gram-positive microorganisms, has been described in previous reports; the first active preparations which were obtained were found to contain a protein precipitable at pH 4.5. It is shown in the p...

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Detalles Bibliográficos
Autores principales: Dubos, René J., Cattaneo, Carlo
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1939
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2133820/
https://www.ncbi.nlm.nih.gov/pubmed/19870906
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author Dubos, René J.
Cattaneo, Carlo
author_facet Dubos, René J.
Cattaneo, Carlo
author_sort Dubos, René J.
collection PubMed
description A cell-free extract of cultures of an unidentified soil bacillus, which exerts a bactericidal effect on Gram-positive microorganisms, has been described in previous reports; the first active preparations which were obtained were found to contain a protein precipitable at pH 4.5. It is shown in the present report that the bactericidal agent can be obtained in an active form free of protein. The new purified preparations retain all the activity of the original material, both in vitro and in vivo.
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spelling pubmed-21338202008-04-18 STUDIES ON A BACTERICIDAL AGENT EXTRACTED FROM A SOIL BACILLUS : III. PREPARATION AND ACTIVITY OF A PROTEIN-FREE FRACTION Dubos, René J. Cattaneo, Carlo J Exp Med Article A cell-free extract of cultures of an unidentified soil bacillus, which exerts a bactericidal effect on Gram-positive microorganisms, has been described in previous reports; the first active preparations which were obtained were found to contain a protein precipitable at pH 4.5. It is shown in the present report that the bactericidal agent can be obtained in an active form free of protein. The new purified preparations retain all the activity of the original material, both in vitro and in vivo. The Rockefeller University Press 1939-08-31 /pmc/articles/PMC2133820/ /pubmed/19870906 Text en Copyright © Copyright, 1939, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Dubos, René J.
Cattaneo, Carlo
STUDIES ON A BACTERICIDAL AGENT EXTRACTED FROM A SOIL BACILLUS : III. PREPARATION AND ACTIVITY OF A PROTEIN-FREE FRACTION
title STUDIES ON A BACTERICIDAL AGENT EXTRACTED FROM A SOIL BACILLUS : III. PREPARATION AND ACTIVITY OF A PROTEIN-FREE FRACTION
title_full STUDIES ON A BACTERICIDAL AGENT EXTRACTED FROM A SOIL BACILLUS : III. PREPARATION AND ACTIVITY OF A PROTEIN-FREE FRACTION
title_fullStr STUDIES ON A BACTERICIDAL AGENT EXTRACTED FROM A SOIL BACILLUS : III. PREPARATION AND ACTIVITY OF A PROTEIN-FREE FRACTION
title_full_unstemmed STUDIES ON A BACTERICIDAL AGENT EXTRACTED FROM A SOIL BACILLUS : III. PREPARATION AND ACTIVITY OF A PROTEIN-FREE FRACTION
title_short STUDIES ON A BACTERICIDAL AGENT EXTRACTED FROM A SOIL BACILLUS : III. PREPARATION AND ACTIVITY OF A PROTEIN-FREE FRACTION
title_sort studies on a bactericidal agent extracted from a soil bacillus : iii. preparation and activity of a protein-free fraction
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2133820/
https://www.ncbi.nlm.nih.gov/pubmed/19870906
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