Genetic incorporation of the protein transduction domain of Tat into Ad5 fiber enhances gene transfer efficacy

BACKGROUND: Human adenovirus serotype 5 (Ad5) has been widely explored as a gene delivery vector for a variety of diseases. Many target cells, however, express low levels of Ad5 native receptor, the Coxsackie-Adenovirus Receptor (CAR), and thus are resistant to Ad5 infection. The Protein Transductio...

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Detalles Bibliográficos
Autores principales: Han, Tie, Tang, Yizhe, Ugai, Hideyo, Perry, Leslie E, Siegal, Gene P, Contreras, Juan L, Wu, Hongju
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2134930/
https://www.ncbi.nlm.nih.gov/pubmed/17958897
http://dx.doi.org/10.1186/1743-422X-4-103

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2134930/
https://www.ncbi.nlm.nih.gov/pubmed/17958897
http://dx.doi.org/10.1186/1743-422X-4-103

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