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Genetic incorporation of the protein transduction domain of Tat into Ad5 fiber enhances gene transfer efficacy

BACKGROUND: Human adenovirus serotype 5 (Ad5) has been widely explored as a gene delivery vector for a variety of diseases. Many target cells, however, express low levels of Ad5 native receptor, the Coxsackie-Adenovirus Receptor (CAR), and thus are resistant to Ad5 infection. The Protein Transductio...

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Detalles Bibliográficos
Autores principales:	Han, Tie, Tang, Yizhe, Ugai, Hideyo, Perry, Leslie E, Siegal, Gene P, Contreras, Juan L, Wu, Hongju
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2007
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2134930/ https://www.ncbi.nlm.nih.gov/pubmed/17958897 http://dx.doi.org/10.1186/1743-422X-4-103

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