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Hemophagocytic Macrophages Harbor Salmonella enterica during Persistent Infection
Salmonella enterica subspecies can establish persistent, systemic infections in mammals, including human typhoid fever. Persistent S. enterica disease is characterized by an initial acute infection that develops into an asymptomatic chronic infection. During both the acute and persistent stages, the...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2134957/ https://www.ncbi.nlm.nih.gov/pubmed/18085823 http://dx.doi.org/10.1371/journal.ppat.0030193 |
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author | Nix, Rebecca N Altschuler, Sarah E Henson, Peter M Detweiler, Corrella S |
author_facet | Nix, Rebecca N Altschuler, Sarah E Henson, Peter M Detweiler, Corrella S |
author_sort | Nix, Rebecca N |
collection | PubMed |
description | Salmonella enterica subspecies can establish persistent, systemic infections in mammals, including human typhoid fever. Persistent S. enterica disease is characterized by an initial acute infection that develops into an asymptomatic chronic infection. During both the acute and persistent stages, the bacteria generally reside within professional phagocytes, usually macrophages. It is unclear how salmonellae can survive within macrophages, cells that evolved, in part, to destroy pathogens. Evidence is presented that during the establishment of persistent murine infection, macrophages that contain S. enterica serotype Typhimurium are hemophagocytic. Hemophagocytic macrophages are characterized by the ingestion of non-apoptotic cells of the hematopoietic lineage and are a clinical marker of typhoid fever as well as certain other infectious and genetic diseases. Cell culture assays were developed to evaluate bacterial survival in hemophagocytic macrophages. S. Typhimurium preferentially replicated in macrophages that pre-phagocytosed viable cells, but the bacteria were killed in macrophages that pre-phagocytosed beads or dead cells. These data suggest that during persistent infection hemophagocytic macrophages may provide S. Typhimurium with a survival niche. |
format | Text |
id | pubmed-2134957 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-21349572007-12-27 Hemophagocytic Macrophages Harbor Salmonella enterica during Persistent Infection Nix, Rebecca N Altschuler, Sarah E Henson, Peter M Detweiler, Corrella S PLoS Pathog Research Article Salmonella enterica subspecies can establish persistent, systemic infections in mammals, including human typhoid fever. Persistent S. enterica disease is characterized by an initial acute infection that develops into an asymptomatic chronic infection. During both the acute and persistent stages, the bacteria generally reside within professional phagocytes, usually macrophages. It is unclear how salmonellae can survive within macrophages, cells that evolved, in part, to destroy pathogens. Evidence is presented that during the establishment of persistent murine infection, macrophages that contain S. enterica serotype Typhimurium are hemophagocytic. Hemophagocytic macrophages are characterized by the ingestion of non-apoptotic cells of the hematopoietic lineage and are a clinical marker of typhoid fever as well as certain other infectious and genetic diseases. Cell culture assays were developed to evaluate bacterial survival in hemophagocytic macrophages. S. Typhimurium preferentially replicated in macrophages that pre-phagocytosed viable cells, but the bacteria were killed in macrophages that pre-phagocytosed beads or dead cells. These data suggest that during persistent infection hemophagocytic macrophages may provide S. Typhimurium with a survival niche. Public Library of Science 2007-12 2007-12-14 /pmc/articles/PMC2134957/ /pubmed/18085823 http://dx.doi.org/10.1371/journal.ppat.0030193 Text en © 2007 Nix et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Nix, Rebecca N Altschuler, Sarah E Henson, Peter M Detweiler, Corrella S Hemophagocytic Macrophages Harbor Salmonella enterica during Persistent Infection |
title | Hemophagocytic Macrophages Harbor Salmonella enterica during Persistent Infection |
title_full | Hemophagocytic Macrophages Harbor Salmonella enterica during Persistent Infection |
title_fullStr | Hemophagocytic Macrophages Harbor Salmonella enterica during Persistent Infection |
title_full_unstemmed | Hemophagocytic Macrophages Harbor Salmonella enterica during Persistent Infection |
title_short | Hemophagocytic Macrophages Harbor Salmonella enterica during Persistent Infection |
title_sort | hemophagocytic macrophages harbor salmonella enterica during persistent infection |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2134957/ https://www.ncbi.nlm.nih.gov/pubmed/18085823 http://dx.doi.org/10.1371/journal.ppat.0030193 |
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