A SOLUBLE ANTIGEN OF LYMPHOCYTIC CHORIOMENINGITIS : II. CHARACTERISTICS OF THE ANTIGEN AND ITS USE IN PRECIPITIN REACTIONS

The soluble antigen of lymphocytic choriomeningitis which is readily separable from the virus is a relatively stable substance and appears to be of a protein nature. A specific precipitin reaction can be demonstrated when immune serum is added to solutions of antigen which have been freed of certain...

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Detalles Bibliográficos
Autores principales: Smadel, J. E., Wall, M. J., Baird, R. D.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1940
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135000/
https://www.ncbi.nlm.nih.gov/pubmed/19870943
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author Smadel, J. E.
Wall, M. J.
Baird, R. D.
author_facet Smadel, J. E.
Wall, M. J.
Baird, R. D.
author_sort Smadel, J. E.
collection PubMed
description The soluble antigen of lymphocytic choriomeningitis which is readily separable from the virus is a relatively stable substance and appears to be of a protein nature. A specific precipitin reaction can be demonstrated when immune serum is added to solutions of antigen which have been freed of certain serologically inactive substances. The complement-fixation and precipitation reactions which occur in the presence of immune serum and non-infectious extracts of splenic tissue obtained from guinea pigs moribund with lymphocytic choriomeningitis seem to be manifestations of union of the same soluble antigen and its antibody. On the other hand, the antisoluble substance antibodies and neutralizing substances appear to be different entities.
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spelling pubmed-21350002008-04-18 A SOLUBLE ANTIGEN OF LYMPHOCYTIC CHORIOMENINGITIS : II. CHARACTERISTICS OF THE ANTIGEN AND ITS USE IN PRECIPITIN REACTIONS Smadel, J. E. Wall, M. J. Baird, R. D. J Exp Med Article The soluble antigen of lymphocytic choriomeningitis which is readily separable from the virus is a relatively stable substance and appears to be of a protein nature. A specific precipitin reaction can be demonstrated when immune serum is added to solutions of antigen which have been freed of certain serologically inactive substances. The complement-fixation and precipitation reactions which occur in the presence of immune serum and non-infectious extracts of splenic tissue obtained from guinea pigs moribund with lymphocytic choriomeningitis seem to be manifestations of union of the same soluble antigen and its antibody. On the other hand, the antisoluble substance antibodies and neutralizing substances appear to be different entities. The Rockefeller University Press 1940-01-01 /pmc/articles/PMC2135000/ /pubmed/19870943 Text en Copyright © Copyright, 1940, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Smadel, J. E.
Wall, M. J.
Baird, R. D.
A SOLUBLE ANTIGEN OF LYMPHOCYTIC CHORIOMENINGITIS : II. CHARACTERISTICS OF THE ANTIGEN AND ITS USE IN PRECIPITIN REACTIONS
title A SOLUBLE ANTIGEN OF LYMPHOCYTIC CHORIOMENINGITIS : II. CHARACTERISTICS OF THE ANTIGEN AND ITS USE IN PRECIPITIN REACTIONS
title_full A SOLUBLE ANTIGEN OF LYMPHOCYTIC CHORIOMENINGITIS : II. CHARACTERISTICS OF THE ANTIGEN AND ITS USE IN PRECIPITIN REACTIONS
title_fullStr A SOLUBLE ANTIGEN OF LYMPHOCYTIC CHORIOMENINGITIS : II. CHARACTERISTICS OF THE ANTIGEN AND ITS USE IN PRECIPITIN REACTIONS
title_full_unstemmed A SOLUBLE ANTIGEN OF LYMPHOCYTIC CHORIOMENINGITIS : II. CHARACTERISTICS OF THE ANTIGEN AND ITS USE IN PRECIPITIN REACTIONS
title_short A SOLUBLE ANTIGEN OF LYMPHOCYTIC CHORIOMENINGITIS : II. CHARACTERISTICS OF THE ANTIGEN AND ITS USE IN PRECIPITIN REACTIONS
title_sort soluble antigen of lymphocytic choriomeningitis : ii. characteristics of the antigen and its use in precipitin reactions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135000/
https://www.ncbi.nlm.nih.gov/pubmed/19870943
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