THE SELECTIVE ACTION OF SULFANILAMIDE ON THE PARASITES OF EXPERIMENTAL MALARIA IN MONKEYS IN VIVO AND IN VITRO

It was found that with mixed malaria infections in the same experimental animal sulfanilamide eradicates a virulent P. knowlesi infection, leaving the animal with a milder chronic P. inui infection. Determinations of the metabolic activity of the two parasites in vitro showed that P. knowlesi consum...

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Detalles Bibliográficos
Autor principal: Coggeshall, L. T.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1940
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135002/
https://www.ncbi.nlm.nih.gov/pubmed/19870940
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author Coggeshall, L. T.
author_facet Coggeshall, L. T.
author_sort Coggeshall, L. T.
collection PubMed
description It was found that with mixed malaria infections in the same experimental animal sulfanilamide eradicates a virulent P. knowlesi infection, leaving the animal with a milder chronic P. inui infection. Determinations of the metabolic activity of the two parasites in vitro showed that P. knowlesi consumed approximately six times more oxygen than P. inui. The addition of sulfanilamide in concentrations less than that necessary to effect a cure almost completely inhibited the respiration of P. knowlesi parasites in vitro, while the same concentrations of the drug against the same number of P. inui parasites had no apparent effect.
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spelling pubmed-21350022008-04-18 THE SELECTIVE ACTION OF SULFANILAMIDE ON THE PARASITES OF EXPERIMENTAL MALARIA IN MONKEYS IN VIVO AND IN VITRO Coggeshall, L. T. J Exp Med Article It was found that with mixed malaria infections in the same experimental animal sulfanilamide eradicates a virulent P. knowlesi infection, leaving the animal with a milder chronic P. inui infection. Determinations of the metabolic activity of the two parasites in vitro showed that P. knowlesi consumed approximately six times more oxygen than P. inui. The addition of sulfanilamide in concentrations less than that necessary to effect a cure almost completely inhibited the respiration of P. knowlesi parasites in vitro, while the same concentrations of the drug against the same number of P. inui parasites had no apparent effect. The Rockefeller University Press 1940-01-01 /pmc/articles/PMC2135002/ /pubmed/19870940 Text en Copyright © Copyright, 1940, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Coggeshall, L. T.
THE SELECTIVE ACTION OF SULFANILAMIDE ON THE PARASITES OF EXPERIMENTAL MALARIA IN MONKEYS IN VIVO AND IN VITRO
title THE SELECTIVE ACTION OF SULFANILAMIDE ON THE PARASITES OF EXPERIMENTAL MALARIA IN MONKEYS IN VIVO AND IN VITRO
title_full THE SELECTIVE ACTION OF SULFANILAMIDE ON THE PARASITES OF EXPERIMENTAL MALARIA IN MONKEYS IN VIVO AND IN VITRO
title_fullStr THE SELECTIVE ACTION OF SULFANILAMIDE ON THE PARASITES OF EXPERIMENTAL MALARIA IN MONKEYS IN VIVO AND IN VITRO
title_full_unstemmed THE SELECTIVE ACTION OF SULFANILAMIDE ON THE PARASITES OF EXPERIMENTAL MALARIA IN MONKEYS IN VIVO AND IN VITRO
title_short THE SELECTIVE ACTION OF SULFANILAMIDE ON THE PARASITES OF EXPERIMENTAL MALARIA IN MONKEYS IN VIVO AND IN VITRO
title_sort selective action of sulfanilamide on the parasites of experimental malaria in monkeys in vivo and in vitro
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135002/
https://www.ncbi.nlm.nih.gov/pubmed/19870940
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