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STUDIES ON THE MECHANISM OF VOMITING PRODUCED BY STAPHYLOCOCCUS ENTEROTOXIN

The emetic action of staphylococcus enterotoxin was tested on young and adult cats under various experimental conditions with the following results: 1. No direct action on isolated intestinal strips was observed. 2. Emesis resulted following intravenous, intracardial, and intraperitoneal injections,...

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Autor principal: Bayliss, Milward
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1940
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135040/
https://www.ncbi.nlm.nih.gov/pubmed/19871052
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author Bayliss, Milward
author_facet Bayliss, Milward
author_sort Bayliss, Milward
collection PubMed
description The emetic action of staphylococcus enterotoxin was tested on young and adult cats under various experimental conditions with the following results: 1. No direct action on isolated intestinal strips was observed. 2. Emesis resulted following intravenous, intracardial, and intraperitoneal injections, but failed to appear subsequent to oral, subcutaneous, or intramuscular administration. 3. Emesis occurred following (a) celiac ganglionectomy, (b) gastrectomy, (c) spinal cord transection at T(2) or caudad, and (d) unilateral vagotomy. 4. Mild retching movements and rarely emesis resulted subsequent to enterotoxin injection following (a) double vagotomy, (b) abdominal evisceration, and (c) spinal cord transection at C(7). 5. Emesis never occurred following (a) destruction of the vomiting center, (b) injection of enterotoxin into the fourth ventricle over the vomiting center, and (c) transection of the central nervous system between the anterior border of the pons and the posterior border of the hypothalamus. 6. Morphine inhibited, ergotoxine inhibited or delayed, while atropine and pentobarbital had little or no effect on emesis due to enterotoxin injection. These experiments indicate that the action of staphylococcus enterotoxin on peripheral sensory structures is of greater importance in the initiation of emesis than direct action of the enterotoxin on the vomiting center. The principal pathways of the afferent and efferent impulses are described.
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spelling pubmed-21350402008-04-18 STUDIES ON THE MECHANISM OF VOMITING PRODUCED BY STAPHYLOCOCCUS ENTEROTOXIN Bayliss, Milward J Exp Med Article The emetic action of staphylococcus enterotoxin was tested on young and adult cats under various experimental conditions with the following results: 1. No direct action on isolated intestinal strips was observed. 2. Emesis resulted following intravenous, intracardial, and intraperitoneal injections, but failed to appear subsequent to oral, subcutaneous, or intramuscular administration. 3. Emesis occurred following (a) celiac ganglionectomy, (b) gastrectomy, (c) spinal cord transection at T(2) or caudad, and (d) unilateral vagotomy. 4. Mild retching movements and rarely emesis resulted subsequent to enterotoxin injection following (a) double vagotomy, (b) abdominal evisceration, and (c) spinal cord transection at C(7). 5. Emesis never occurred following (a) destruction of the vomiting center, (b) injection of enterotoxin into the fourth ventricle over the vomiting center, and (c) transection of the central nervous system between the anterior border of the pons and the posterior border of the hypothalamus. 6. Morphine inhibited, ergotoxine inhibited or delayed, while atropine and pentobarbital had little or no effect on emesis due to enterotoxin injection. These experiments indicate that the action of staphylococcus enterotoxin on peripheral sensory structures is of greater importance in the initiation of emesis than direct action of the enterotoxin on the vomiting center. The principal pathways of the afferent and efferent impulses are described. The Rockefeller University Press 1940-11-30 /pmc/articles/PMC2135040/ /pubmed/19871052 Text en Copyright © Copyright, 1940, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Bayliss, Milward
STUDIES ON THE MECHANISM OF VOMITING PRODUCED BY STAPHYLOCOCCUS ENTEROTOXIN
title STUDIES ON THE MECHANISM OF VOMITING PRODUCED BY STAPHYLOCOCCUS ENTEROTOXIN
title_full STUDIES ON THE MECHANISM OF VOMITING PRODUCED BY STAPHYLOCOCCUS ENTEROTOXIN
title_fullStr STUDIES ON THE MECHANISM OF VOMITING PRODUCED BY STAPHYLOCOCCUS ENTEROTOXIN
title_full_unstemmed STUDIES ON THE MECHANISM OF VOMITING PRODUCED BY STAPHYLOCOCCUS ENTEROTOXIN
title_short STUDIES ON THE MECHANISM OF VOMITING PRODUCED BY STAPHYLOCOCCUS ENTEROTOXIN
title_sort studies on the mechanism of vomiting produced by staphylococcus enterotoxin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135040/
https://www.ncbi.nlm.nih.gov/pubmed/19871052
work_keys_str_mv AT baylissmilward studiesonthemechanismofvomitingproducedbystaphylococcusenterotoxin