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A STUDY OF THE NEUROTROPIC TENDENCY IN STRAINS OF THE VIRUS OF EPIDEMIC INFLUENZA

The demonstration by Stuart-Harris that the W.S. strain of epidemic influenza virus can induce a fatal nervous disease in mice has been confirmed. In contrast, however, no previous period of adaptation to chick embryonic brain was required. By serial brain to brain passages in mice originally inocul...

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Detalles Bibliográficos
Autores principales: Francis, Thomas, Moore, Alice E.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1940
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135049/
https://www.ncbi.nlm.nih.gov/pubmed/19871056
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author Francis, Thomas
Moore, Alice E.
author_facet Francis, Thomas
Moore, Alice E.
author_sort Francis, Thomas
collection PubMed
description The demonstration by Stuart-Harris that the W.S. strain of epidemic influenza virus can induce a fatal nervous disease in mice has been confirmed. In contrast, however, no previous period of adaptation to chick embryonic brain was required. By serial brain to brain passages in mice originally inoculated with the virus cultivated in the usual chick embryo culture medium a fatal disease, essentially meningeal in character, is produced. The Melbourne strain has been similarly enhanced while other strains have failed to reveal any neurotropic tendencies. The evidence indicates that the neurotropic characteristic is present in the two strains as an inherent quality which is quantitatively heightened and does not represent the acquisition of a property not previously present.
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spelling pubmed-21350492008-04-18 A STUDY OF THE NEUROTROPIC TENDENCY IN STRAINS OF THE VIRUS OF EPIDEMIC INFLUENZA Francis, Thomas Moore, Alice E. J Exp Med Article The demonstration by Stuart-Harris that the W.S. strain of epidemic influenza virus can induce a fatal nervous disease in mice has been confirmed. In contrast, however, no previous period of adaptation to chick embryonic brain was required. By serial brain to brain passages in mice originally inoculated with the virus cultivated in the usual chick embryo culture medium a fatal disease, essentially meningeal in character, is produced. The Melbourne strain has been similarly enhanced while other strains have failed to reveal any neurotropic tendencies. The evidence indicates that the neurotropic characteristic is present in the two strains as an inherent quality which is quantitatively heightened and does not represent the acquisition of a property not previously present. The Rockefeller University Press 1940-11-30 /pmc/articles/PMC2135049/ /pubmed/19871056 Text en Copyright © Copyright, 1940, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Francis, Thomas
Moore, Alice E.
A STUDY OF THE NEUROTROPIC TENDENCY IN STRAINS OF THE VIRUS OF EPIDEMIC INFLUENZA
title A STUDY OF THE NEUROTROPIC TENDENCY IN STRAINS OF THE VIRUS OF EPIDEMIC INFLUENZA
title_full A STUDY OF THE NEUROTROPIC TENDENCY IN STRAINS OF THE VIRUS OF EPIDEMIC INFLUENZA
title_fullStr A STUDY OF THE NEUROTROPIC TENDENCY IN STRAINS OF THE VIRUS OF EPIDEMIC INFLUENZA
title_full_unstemmed A STUDY OF THE NEUROTROPIC TENDENCY IN STRAINS OF THE VIRUS OF EPIDEMIC INFLUENZA
title_short A STUDY OF THE NEUROTROPIC TENDENCY IN STRAINS OF THE VIRUS OF EPIDEMIC INFLUENZA
title_sort study of the neurotropic tendency in strains of the virus of epidemic influenza
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135049/
https://www.ncbi.nlm.nih.gov/pubmed/19871056
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