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AMINO ACIDS AND HEMOGLOBIN PRODUCTION IN ANEMIA

Certain individual amino acids when given to standard anemic dogs cause an increase in new hemoglobin production. Occasional negative experiments are recorded. Glycine, glutamic acid, aspartic acid, cystine, histidine, phenylalanine, and proline when given in 1 gm. doses daily for 2 weeks, increase...

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Detalles Bibliográficos
Autores principales: Whipple, G. H., Robscheit-Robbins, F. S.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1940
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135081/
https://www.ncbi.nlm.nih.gov/pubmed/19870982
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author Whipple, G. H.
Robscheit-Robbins, F. S.
author_facet Whipple, G. H.
Robscheit-Robbins, F. S.
author_sort Whipple, G. H.
collection PubMed
description Certain individual amino acids when given to standard anemic dogs cause an increase in new hemoglobin production. Occasional negative experiments are recorded. Glycine, glutamic acid, aspartic acid, cystine, histidine, phenylalanine, and proline when given in 1 gm. doses daily for 2 weeks, increase hemoglobin output on the average 23 to 25 gm. above the control level. This reaction amounts to 25 to 30 per cent of the new hemoglobin produced by the feeding of 300 gm. liver daily for 2 weeks—a standard liver test. Alanine, valine, isoleucine, and arginine in the same dosage increase the hemoglobin output on the average 13 to 17 gm. per 2 weeks over the control level. Leucine, methionine, lysine, tryptophane, and tyrosine fall in a middle group with hemoglobin output of about 20 gm. Isovaleric acid, β-hydroxybutyric acid, glutaric acid, and asparagine have shown positive effects and the butyrate is unusually potent for hemoglobin production (Table 2). The isomeric and dl-synthetic forms of the amino acids are as effectively utilized in this reaction as are the natural forms.
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spelling pubmed-21350812008-04-18 AMINO ACIDS AND HEMOGLOBIN PRODUCTION IN ANEMIA Whipple, G. H. Robscheit-Robbins, F. S. J Exp Med Article Certain individual amino acids when given to standard anemic dogs cause an increase in new hemoglobin production. Occasional negative experiments are recorded. Glycine, glutamic acid, aspartic acid, cystine, histidine, phenylalanine, and proline when given in 1 gm. doses daily for 2 weeks, increase hemoglobin output on the average 23 to 25 gm. above the control level. This reaction amounts to 25 to 30 per cent of the new hemoglobin produced by the feeding of 300 gm. liver daily for 2 weeks—a standard liver test. Alanine, valine, isoleucine, and arginine in the same dosage increase the hemoglobin output on the average 13 to 17 gm. per 2 weeks over the control level. Leucine, methionine, lysine, tryptophane, and tyrosine fall in a middle group with hemoglobin output of about 20 gm. Isovaleric acid, β-hydroxybutyric acid, glutaric acid, and asparagine have shown positive effects and the butyrate is unusually potent for hemoglobin production (Table 2). The isomeric and dl-synthetic forms of the amino acids are as effectively utilized in this reaction as are the natural forms. The Rockefeller University Press 1940-03-31 /pmc/articles/PMC2135081/ /pubmed/19870982 Text en Copyright © Copyright, 1940, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Whipple, G. H.
Robscheit-Robbins, F. S.
AMINO ACIDS AND HEMOGLOBIN PRODUCTION IN ANEMIA
title AMINO ACIDS AND HEMOGLOBIN PRODUCTION IN ANEMIA
title_full AMINO ACIDS AND HEMOGLOBIN PRODUCTION IN ANEMIA
title_fullStr AMINO ACIDS AND HEMOGLOBIN PRODUCTION IN ANEMIA
title_full_unstemmed AMINO ACIDS AND HEMOGLOBIN PRODUCTION IN ANEMIA
title_short AMINO ACIDS AND HEMOGLOBIN PRODUCTION IN ANEMIA
title_sort amino acids and hemoglobin production in anemia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135081/
https://www.ncbi.nlm.nih.gov/pubmed/19870982
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