SOME PROPERTIES OF THE ENCEPHALOPATHIC AGENT IN PRIMATE BONE MARROW (THE GORDON AGENT)

The nature of the encephalopathic agent present in monkey bone marrow has been investigated. It is readily soluble at a pH of 7.4, as well as at the low pH of 2.0 and 3.0. The point of minimal solubility is pH 4.2. Heat inactivation is produced by a temperature of 75°C., acting for 15 minutes. The a...

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Autor principal: King, Lester S.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1940
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135098/
https://www.ncbi.nlm.nih.gov/pubmed/19870985
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author King, Lester S.
author_facet King, Lester S.
author_sort King, Lester S.
collection PubMed
description The nature of the encephalopathic agent present in monkey bone marrow has been investigated. It is readily soluble at a pH of 7.4, as well as at the low pH of 2.0 and 3.0. The point of minimal solubility is pH 4.2. Heat inactivation is produced by a temperature of 75°C., acting for 15 minutes. The agent is digested by pepsin. It exhibits a slight degree of sedimentation with the air-driven centrifuge. It is non-dialyzable. It is precipitated from solution (pH 7.4) by ammonium sulfate, over a range of 0.4 to 0.8 saturation. These findings all suggest that the agent is a protein. No immunological reactions could be elicited.
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spelling pubmed-21350982008-04-18 SOME PROPERTIES OF THE ENCEPHALOPATHIC AGENT IN PRIMATE BONE MARROW (THE GORDON AGENT) King, Lester S. J Exp Med Article The nature of the encephalopathic agent present in monkey bone marrow has been investigated. It is readily soluble at a pH of 7.4, as well as at the low pH of 2.0 and 3.0. The point of minimal solubility is pH 4.2. Heat inactivation is produced by a temperature of 75°C., acting for 15 minutes. The agent is digested by pepsin. It exhibits a slight degree of sedimentation with the air-driven centrifuge. It is non-dialyzable. It is precipitated from solution (pH 7.4) by ammonium sulfate, over a range of 0.4 to 0.8 saturation. These findings all suggest that the agent is a protein. No immunological reactions could be elicited. The Rockefeller University Press 1940-04-30 /pmc/articles/PMC2135098/ /pubmed/19870985 Text en Copyright © Copyright, 1940, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
King, Lester S.
SOME PROPERTIES OF THE ENCEPHALOPATHIC AGENT IN PRIMATE BONE MARROW (THE GORDON AGENT)
title SOME PROPERTIES OF THE ENCEPHALOPATHIC AGENT IN PRIMATE BONE MARROW (THE GORDON AGENT)
title_full SOME PROPERTIES OF THE ENCEPHALOPATHIC AGENT IN PRIMATE BONE MARROW (THE GORDON AGENT)
title_fullStr SOME PROPERTIES OF THE ENCEPHALOPATHIC AGENT IN PRIMATE BONE MARROW (THE GORDON AGENT)
title_full_unstemmed SOME PROPERTIES OF THE ENCEPHALOPATHIC AGENT IN PRIMATE BONE MARROW (THE GORDON AGENT)
title_short SOME PROPERTIES OF THE ENCEPHALOPATHIC AGENT IN PRIMATE BONE MARROW (THE GORDON AGENT)
title_sort some properties of the encephalopathic agent in primate bone marrow (the gordon agent)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135098/
https://www.ncbi.nlm.nih.gov/pubmed/19870985
work_keys_str_mv AT kinglesters somepropertiesoftheencephalopathicagentinprimatebonemarrowthegordonagent

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