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CIRRHOSIS OF THE LIVER CAUSED BY EXCESS DIETARY CYSTINE
1. Cystine fed to young albino rats as 10 per cent of the diet resulted in: (a) Portal hemorrhagic necrosis, resembling eclampsia, within 3 or 4 days. (b) A high mortality rate. (c) Fatty infiltration of hepatic cells in all rats surviving the initial acute lesion. (d) Cirrhosis of the liver in rats...
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
1941
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135120/ https://www.ncbi.nlm.nih.gov/pubmed/19871069 |
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author | Earle, David P. Victor, Joseph |
author_facet | Earle, David P. Victor, Joseph |
author_sort | Earle, David P. |
collection | PubMed |
description | 1. Cystine fed to young albino rats as 10 per cent of the diet resulted in: (a) Portal hemorrhagic necrosis, resembling eclampsia, within 3 or 4 days. (b) A high mortality rate. (c) Fatty infiltration of hepatic cells in all rats surviving the initial acute lesion. (d) Cirrhosis of the liver in rats surviving more than 2 weeks. 2. 5 per cent dietary cystine produced marked fatty infiltration of the liver, followed by portal hemorrhagic necrosis. Cirrhosis was present in one of the two rats on the diet for 6 weeks. 3. The livers of rats fed 5 or 10 per cent cystine diets followed by the McCollum stock diet, showed evidence of residual cellular damage, and of regeneration as shown by mitotic figures. 4. In this series of 30 rats on excess dietary cystine, a renal lesion was found in only one case. |
format | Text |
id | pubmed-2135120 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1941 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21351202008-04-18 CIRRHOSIS OF THE LIVER CAUSED BY EXCESS DIETARY CYSTINE Earle, David P. Victor, Joseph J Exp Med Article 1. Cystine fed to young albino rats as 10 per cent of the diet resulted in: (a) Portal hemorrhagic necrosis, resembling eclampsia, within 3 or 4 days. (b) A high mortality rate. (c) Fatty infiltration of hepatic cells in all rats surviving the initial acute lesion. (d) Cirrhosis of the liver in rats surviving more than 2 weeks. 2. 5 per cent dietary cystine produced marked fatty infiltration of the liver, followed by portal hemorrhagic necrosis. Cirrhosis was present in one of the two rats on the diet for 6 weeks. 3. The livers of rats fed 5 or 10 per cent cystine diets followed by the McCollum stock diet, showed evidence of residual cellular damage, and of regeneration as shown by mitotic figures. 4. In this series of 30 rats on excess dietary cystine, a renal lesion was found in only one case. The Rockefeller University Press 1941-01-31 /pmc/articles/PMC2135120/ /pubmed/19871069 Text en Copyright © Copyright, 1941, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Earle, David P. Victor, Joseph CIRRHOSIS OF THE LIVER CAUSED BY EXCESS DIETARY CYSTINE |
title | CIRRHOSIS OF THE LIVER CAUSED BY EXCESS DIETARY CYSTINE |
title_full | CIRRHOSIS OF THE LIVER CAUSED BY EXCESS DIETARY CYSTINE |
title_fullStr | CIRRHOSIS OF THE LIVER CAUSED BY EXCESS DIETARY CYSTINE |
title_full_unstemmed | CIRRHOSIS OF THE LIVER CAUSED BY EXCESS DIETARY CYSTINE |
title_short | CIRRHOSIS OF THE LIVER CAUSED BY EXCESS DIETARY CYSTINE |
title_sort | cirrhosis of the liver caused by excess dietary cystine |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135120/ https://www.ncbi.nlm.nih.gov/pubmed/19871069 |
work_keys_str_mv | AT earledavidp cirrhosisofthelivercausedbyexcessdietarycystine AT victorjoseph cirrhosisofthelivercausedbyexcessdietarycystine |