THE EFFECT OF TYROSINASE ON EXPERIMENTAL HYPERTENSION

1. The intravenous injection of tyrosinase, a phenolic oxidase obtained from mushrooms, consistently lowers the blood pressure of rats made hypertensive by three different methods, while on the average not affecting the blood pressure of normal animals. 2. The intravenous and intramuscular injection...

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Detalles Bibliográficos
Autores principales: Schroeder, Henry A., Adams, Mark H.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1941
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135141/
https://www.ncbi.nlm.nih.gov/pubmed/19871095
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author Schroeder, Henry A.
Adams, Mark H.
author_facet Schroeder, Henry A.
Adams, Mark H.
author_sort Schroeder, Henry A.
collection PubMed
description 1. The intravenous injection of tyrosinase, a phenolic oxidase obtained from mushrooms, consistently lowers the blood pressure of rats made hypertensive by three different methods, while on the average not affecting the blood pressure of normal animals. 2. The intravenous and intramuscular injection of tyrosinase lowers blood pressure in dogs made hypertensive by the method of Goldblatt, while affecting that of normal ones to a less extent. 3. Tyrosinase inactivates renin, angiotonin, Victor's pressor substance, adrenalin, and tyramine in vitro, and alters the response of the blood pressure to these substances in rats and dogs. 4. Renal function of hypertensive dogs is not depressed when the blood pressure is lowered by tyrosinase. 5. Tyrosinase is an effective substance for combating experimental arterial hypertension. It is probable that some phenolic substance present in hypertension is altered.
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spelling pubmed-21351412008-04-18 THE EFFECT OF TYROSINASE ON EXPERIMENTAL HYPERTENSION Schroeder, Henry A. Adams, Mark H. J Exp Med Article 1. The intravenous injection of tyrosinase, a phenolic oxidase obtained from mushrooms, consistently lowers the blood pressure of rats made hypertensive by three different methods, while on the average not affecting the blood pressure of normal animals. 2. The intravenous and intramuscular injection of tyrosinase lowers blood pressure in dogs made hypertensive by the method of Goldblatt, while affecting that of normal ones to a less extent. 3. Tyrosinase inactivates renin, angiotonin, Victor's pressor substance, adrenalin, and tyramine in vitro, and alters the response of the blood pressure to these substances in rats and dogs. 4. Renal function of hypertensive dogs is not depressed when the blood pressure is lowered by tyrosinase. 5. Tyrosinase is an effective substance for combating experimental arterial hypertension. It is probable that some phenolic substance present in hypertension is altered. The Rockefeller University Press 1941-03-31 /pmc/articles/PMC2135141/ /pubmed/19871095 Text en Copyright © Copyright, 1941, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Schroeder, Henry A.
Adams, Mark H.
THE EFFECT OF TYROSINASE ON EXPERIMENTAL HYPERTENSION
title THE EFFECT OF TYROSINASE ON EXPERIMENTAL HYPERTENSION
title_full THE EFFECT OF TYROSINASE ON EXPERIMENTAL HYPERTENSION
title_fullStr THE EFFECT OF TYROSINASE ON EXPERIMENTAL HYPERTENSION
title_full_unstemmed THE EFFECT OF TYROSINASE ON EXPERIMENTAL HYPERTENSION
title_short THE EFFECT OF TYROSINASE ON EXPERIMENTAL HYPERTENSION
title_sort effect of tyrosinase on experimental hypertension
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135141/
https://www.ncbi.nlm.nih.gov/pubmed/19871095
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