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COMPARATIVE VIRULENCE OF ST. LOUIS ENCEPHALITIS VIRUS CULTURED WITH BRAIN TISSUE FROM INNATELY SUSCEPTIBLE AND INNATELY RESISTANT MICE

We find that St. Louis encephalitis virus cultured in 10 per cent serum-Tyrode solution plus brain tissue from 1-day-old innately susceptible mice attains a higher titre than when cultured in a similar solution plus brain tissue from 1-day-old closely related, yet innately resistant mice. This diffe...

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Detalles Bibliográficos
Autores principales: Webster, L. T., Johnson, Mary S.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1941
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135194/
https://www.ncbi.nlm.nih.gov/pubmed/19871149
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author Webster, L. T.
Johnson, Mary S.
author_facet Webster, L. T.
Johnson, Mary S.
author_sort Webster, L. T.
collection PubMed
description We find that St. Louis encephalitis virus cultured in 10 per cent serum-Tyrode solution plus brain tissue from 1-day-old innately susceptible mice attains a higher titre than when cultured in a similar solution plus brain tissue from 1-day-old closely related, yet innately resistant mice. This difference in titre persists regardless of whether the serum comes from innately susceptible or resistant mice. The relatively high titre of virus in the susceptible media is not affected by the addition of an extract (not cell-free) from the resistant brain; the relatively low titre of the virus in the resistant media may possibly be slightly enhanced by the addition of an extract from the susceptible brain. The findings as a whole show that the marked difference in the increase of St. Louis encephalitis virus in the brain tissue of innately susceptible and resistant mice, on culture in vitro, is due to some difference in the brain tissue itself.
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spelling pubmed-21351942008-04-18 COMPARATIVE VIRULENCE OF ST. LOUIS ENCEPHALITIS VIRUS CULTURED WITH BRAIN TISSUE FROM INNATELY SUSCEPTIBLE AND INNATELY RESISTANT MICE Webster, L. T. Johnson, Mary S. J Exp Med Article We find that St. Louis encephalitis virus cultured in 10 per cent serum-Tyrode solution plus brain tissue from 1-day-old innately susceptible mice attains a higher titre than when cultured in a similar solution plus brain tissue from 1-day-old closely related, yet innately resistant mice. This difference in titre persists regardless of whether the serum comes from innately susceptible or resistant mice. The relatively high titre of virus in the susceptible media is not affected by the addition of an extract (not cell-free) from the resistant brain; the relatively low titre of the virus in the resistant media may possibly be slightly enhanced by the addition of an extract from the susceptible brain. The findings as a whole show that the marked difference in the increase of St. Louis encephalitis virus in the brain tissue of innately susceptible and resistant mice, on culture in vitro, is due to some difference in the brain tissue itself. The Rockefeller University Press 1941-10-31 /pmc/articles/PMC2135194/ /pubmed/19871149 Text en Copyright © Copyright, 1941, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Webster, L. T.
Johnson, Mary S.
COMPARATIVE VIRULENCE OF ST. LOUIS ENCEPHALITIS VIRUS CULTURED WITH BRAIN TISSUE FROM INNATELY SUSCEPTIBLE AND INNATELY RESISTANT MICE
title COMPARATIVE VIRULENCE OF ST. LOUIS ENCEPHALITIS VIRUS CULTURED WITH BRAIN TISSUE FROM INNATELY SUSCEPTIBLE AND INNATELY RESISTANT MICE
title_full COMPARATIVE VIRULENCE OF ST. LOUIS ENCEPHALITIS VIRUS CULTURED WITH BRAIN TISSUE FROM INNATELY SUSCEPTIBLE AND INNATELY RESISTANT MICE
title_fullStr COMPARATIVE VIRULENCE OF ST. LOUIS ENCEPHALITIS VIRUS CULTURED WITH BRAIN TISSUE FROM INNATELY SUSCEPTIBLE AND INNATELY RESISTANT MICE
title_full_unstemmed COMPARATIVE VIRULENCE OF ST. LOUIS ENCEPHALITIS VIRUS CULTURED WITH BRAIN TISSUE FROM INNATELY SUSCEPTIBLE AND INNATELY RESISTANT MICE
title_short COMPARATIVE VIRULENCE OF ST. LOUIS ENCEPHALITIS VIRUS CULTURED WITH BRAIN TISSUE FROM INNATELY SUSCEPTIBLE AND INNATELY RESISTANT MICE
title_sort comparative virulence of st. louis encephalitis virus cultured with brain tissue from innately susceptible and innately resistant mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135194/
https://www.ncbi.nlm.nih.gov/pubmed/19871149
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