THE EFFECT OF SULFAPYRIDINE UPON THE DEVELOPMENT OF IMMUNITY TO PNEUMOCOCCUS IN RABBITS

1. Sulfapyridine, administered to rabbits during the period of developing immunity after a single intravenous injection of heat-killed Pneumococcus Type I, exerted no influence upon the immune response. 2. Active immunity as indicated by increased resistance to homologous intradermal infection was p...

Descripción completa

Detalles Bibliográficos
Autores principales: Curnen, Edward C., MacLeod, Colin M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1942
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135219/
https://www.ncbi.nlm.nih.gov/pubmed/19871170
_version_ 1782142845330653184
author Curnen, Edward C.
MacLeod, Colin M.
author_facet Curnen, Edward C.
MacLeod, Colin M.
author_sort Curnen, Edward C.
collection PubMed
description 1. Sulfapyridine, administered to rabbits during the period of developing immunity after a single intravenous injection of heat-killed Pneumococcus Type I, exerted no influence upon the immune response. 2. Active immunity as indicated by increased resistance to homologous intradermal infection was present 48 hours after the immunizing injection and 2 days before circulating type specific antibodies were detectable. 3. Of the serological techniques employed for the detection of circulating antibody the mouse protective test yielded the highest percentage of positive results followed in order by tests for type specific agglutinins and precipitins, the latter being least satisfactory for the detection of small amounts of antibody.
format Text
id pubmed-2135219
institution National Center for Biotechnology Information
language English
publishDate 1942
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21352192008-04-18 THE EFFECT OF SULFAPYRIDINE UPON THE DEVELOPMENT OF IMMUNITY TO PNEUMOCOCCUS IN RABBITS Curnen, Edward C. MacLeod, Colin M. J Exp Med Article 1. Sulfapyridine, administered to rabbits during the period of developing immunity after a single intravenous injection of heat-killed Pneumococcus Type I, exerted no influence upon the immune response. 2. Active immunity as indicated by increased resistance to homologous intradermal infection was present 48 hours after the immunizing injection and 2 days before circulating type specific antibodies were detectable. 3. Of the serological techniques employed for the detection of circulating antibody the mouse protective test yielded the highest percentage of positive results followed in order by tests for type specific agglutinins and precipitins, the latter being least satisfactory for the detection of small amounts of antibody. The Rockefeller University Press 1942-01-01 /pmc/articles/PMC2135219/ /pubmed/19871170 Text en Copyright © Copyright, 1942, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Curnen, Edward C.
MacLeod, Colin M.
THE EFFECT OF SULFAPYRIDINE UPON THE DEVELOPMENT OF IMMUNITY TO PNEUMOCOCCUS IN RABBITS
title THE EFFECT OF SULFAPYRIDINE UPON THE DEVELOPMENT OF IMMUNITY TO PNEUMOCOCCUS IN RABBITS
title_full THE EFFECT OF SULFAPYRIDINE UPON THE DEVELOPMENT OF IMMUNITY TO PNEUMOCOCCUS IN RABBITS
title_fullStr THE EFFECT OF SULFAPYRIDINE UPON THE DEVELOPMENT OF IMMUNITY TO PNEUMOCOCCUS IN RABBITS
title_full_unstemmed THE EFFECT OF SULFAPYRIDINE UPON THE DEVELOPMENT OF IMMUNITY TO PNEUMOCOCCUS IN RABBITS
title_short THE EFFECT OF SULFAPYRIDINE UPON THE DEVELOPMENT OF IMMUNITY TO PNEUMOCOCCUS IN RABBITS
title_sort effect of sulfapyridine upon the development of immunity to pneumococcus in rabbits
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135219/
https://www.ncbi.nlm.nih.gov/pubmed/19871170
work_keys_str_mv AT curnenedwardc theeffectofsulfapyridineuponthedevelopmentofimmunitytopneumococcusinrabbits
AT macleodcolinm theeffectofsulfapyridineuponthedevelopmentofimmunitytopneumococcusinrabbits
AT curnenedwardc effectofsulfapyridineuponthedevelopmentofimmunitytopneumococcusinrabbits
AT macleodcolinm effectofsulfapyridineuponthedevelopmentofimmunitytopneumococcusinrabbits

Ejemplares similares