LYMPHOCYTIC CHORIOMENINGITIS IN THE SYRIAN HAMSTER

The virus of lymphocytic choriomeningitis produces an intense systemic infection in Syrian hamsters with few if any clinical and pathological signs of disease. Specific soluble antigen is demonstrable in the spleen of infected animals until about the 14th day when antisoluble substance antibodies ma...

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Detalles Bibliográficos
Autores principales: Smadel, J. E., Wall, M. J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1942
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135273/
https://www.ncbi.nlm.nih.gov/pubmed/19871208
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author Smadel, J. E.
Wall, M. J.
author_facet Smadel, J. E.
Wall, M. J.
author_sort Smadel, J. E.
collection PubMed
description The virus of lymphocytic choriomeningitis produces an intense systemic infection in Syrian hamsters with few if any clinical and pathological signs of disease. Specific soluble antigen is demonstrable in the spleen of infected animals until about the 14th day when antisoluble substance antibodies make their appearance. Circulating virus disappears after the 4th week and neutralizing antibodies are present in serum in detectable amounts shortly thereafter; both types of antibody persist for at least several months. The viruses of St. Louis encephalitis and lymphocytic choriomeningitis can be concurrently passed in series in the brains of hamsters. The resultant disease is indistinguishable from that caused by the virus of St. Louis encephalitis alone.
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spelling pubmed-21352732008-04-18 LYMPHOCYTIC CHORIOMENINGITIS IN THE SYRIAN HAMSTER Smadel, J. E. Wall, M. J. J Exp Med Article The virus of lymphocytic choriomeningitis produces an intense systemic infection in Syrian hamsters with few if any clinical and pathological signs of disease. Specific soluble antigen is demonstrable in the spleen of infected animals until about the 14th day when antisoluble substance antibodies make their appearance. Circulating virus disappears after the 4th week and neutralizing antibodies are present in serum in detectable amounts shortly thereafter; both types of antibody persist for at least several months. The viruses of St. Louis encephalitis and lymphocytic choriomeningitis can be concurrently passed in series in the brains of hamsters. The resultant disease is indistinguishable from that caused by the virus of St. Louis encephalitis alone. The Rockefeller University Press 1942-06-01 /pmc/articles/PMC2135273/ /pubmed/19871208 Text en Copyright © Copyright, 1942, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Smadel, J. E.
Wall, M. J.
LYMPHOCYTIC CHORIOMENINGITIS IN THE SYRIAN HAMSTER
title LYMPHOCYTIC CHORIOMENINGITIS IN THE SYRIAN HAMSTER
title_full LYMPHOCYTIC CHORIOMENINGITIS IN THE SYRIAN HAMSTER
title_fullStr LYMPHOCYTIC CHORIOMENINGITIS IN THE SYRIAN HAMSTER
title_full_unstemmed LYMPHOCYTIC CHORIOMENINGITIS IN THE SYRIAN HAMSTER
title_short LYMPHOCYTIC CHORIOMENINGITIS IN THE SYRIAN HAMSTER
title_sort lymphocytic choriomeningitis in the syrian hamster
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135273/
https://www.ncbi.nlm.nih.gov/pubmed/19871208
work_keys_str_mv AT smadelje lymphocyticchoriomeningitisinthesyrianhamster
AT wallmj lymphocyticchoriomeningitisinthesyrianhamster

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