METHIONINE PROTECTS AGAINST MAPHARSEN LIVER INJURY IN PROTEIN-DEPLETED DOGS

Depletion of body protein stores by means of low protein diet or plasmapheresis causes greater susceptibility to liver injury by the arsenical compound, mapharsen. Normal dogs can tolerate mapharsen in doses of 0.006 to 0.008 gm. per kilo whereas in protein-depleted dogs doses of 0.002 to 0.0025 gm....

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Detalles Bibliográficos
Autores principales: Goodell, J. P. B., Hanson, P. C., Hawkins, W. B.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1944
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135380/
https://www.ncbi.nlm.nih.gov/pubmed/19871391
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author Goodell, J. P. B.
Hanson, P. C.
Hawkins, W. B.
author_facet Goodell, J. P. B.
Hanson, P. C.
Hawkins, W. B.
author_sort Goodell, J. P. B.
collection PubMed
description Depletion of body protein stores by means of low protein diet or plasmapheresis causes greater susceptibility to liver injury by the arsenical compound, mapharsen. Normal dogs can tolerate mapharsen in doses of 0.006 to 0.008 gm. per kilo whereas in protein-depleted dogs doses of 0.002 to 0.0025 gm. per kilo cause liver injury with jaundice. Methionine (2 to 4 gm.) given by mouth 20 to 24 hours prior to administration of mapharsen is protective and the dogs will tolerate 0.0045 gm. per kilo with no icterus developing. Methionine (1 gm.) intravenously just prior to mapharsen injection is not as consistent in effecting protection, but the smaller dose may be responsible.
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spelling pubmed-21353802008-04-18 METHIONINE PROTECTS AGAINST MAPHARSEN LIVER INJURY IN PROTEIN-DEPLETED DOGS Goodell, J. P. B. Hanson, P. C. Hawkins, W. B. J Exp Med Article Depletion of body protein stores by means of low protein diet or plasmapheresis causes greater susceptibility to liver injury by the arsenical compound, mapharsen. Normal dogs can tolerate mapharsen in doses of 0.006 to 0.008 gm. per kilo whereas in protein-depleted dogs doses of 0.002 to 0.0025 gm. per kilo cause liver injury with jaundice. Methionine (2 to 4 gm.) given by mouth 20 to 24 hours prior to administration of mapharsen is protective and the dogs will tolerate 0.0045 gm. per kilo with no icterus developing. Methionine (1 gm.) intravenously just prior to mapharsen injection is not as consistent in effecting protection, but the smaller dose may be responsible. The Rockefeller University Press 1944-06-01 /pmc/articles/PMC2135380/ /pubmed/19871391 Text en Copyright © Copyright, 1944, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Goodell, J. P. B.
Hanson, P. C.
Hawkins, W. B.
METHIONINE PROTECTS AGAINST MAPHARSEN LIVER INJURY IN PROTEIN-DEPLETED DOGS
title METHIONINE PROTECTS AGAINST MAPHARSEN LIVER INJURY IN PROTEIN-DEPLETED DOGS
title_full METHIONINE PROTECTS AGAINST MAPHARSEN LIVER INJURY IN PROTEIN-DEPLETED DOGS
title_fullStr METHIONINE PROTECTS AGAINST MAPHARSEN LIVER INJURY IN PROTEIN-DEPLETED DOGS
title_full_unstemmed METHIONINE PROTECTS AGAINST MAPHARSEN LIVER INJURY IN PROTEIN-DEPLETED DOGS
title_short METHIONINE PROTECTS AGAINST MAPHARSEN LIVER INJURY IN PROTEIN-DEPLETED DOGS
title_sort methionine protects against mapharsen liver injury in protein-depleted dogs
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135380/
https://www.ncbi.nlm.nih.gov/pubmed/19871391
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