THERAPEUTIC EFFECTIVENESS OF PENICILLIN IN EXPERIMENTAL MURINE TYPHUS INFECTION IN dba MICE

The administration of penicillin in relatively large but non-toxic doses to dba mice after injection with murine typhus rickettsiae resulted in a marked reduction in mortality, particularly when the initial dosage of rickettsiae was relatively small, approaching the minimal lethal dose. No evidence...

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Detalles Bibliográficos
Autores principales: Moragues, Vicente, Pinkerton, Henry, Greiff, Donald
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1944
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135392/
https://www.ncbi.nlm.nih.gov/pubmed/19871379
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author Moragues, Vicente
Pinkerton, Henry
Greiff, Donald
author_facet Moragues, Vicente
Pinkerton, Henry
Greiff, Donald
author_sort Moragues, Vicente
collection PubMed
description The administration of penicillin in relatively large but non-toxic doses to dba mice after injection with murine typhus rickettsiae resulted in a marked reduction in mortality, particularly when the initial dosage of rickettsiae was relatively small, approaching the minimal lethal dose. No evidence of secondary bacterial infection was obtained by bacteriological and histological studies, and it seems justifiable to conclude that the greatly increased survival rate in the treated mice was caused by the action of penicillin on typhus rickettsiae. The theoretical and practical implications of the results are discussed.
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spelling pubmed-21353922008-04-18 THERAPEUTIC EFFECTIVENESS OF PENICILLIN IN EXPERIMENTAL MURINE TYPHUS INFECTION IN dba MICE Moragues, Vicente Pinkerton, Henry Greiff, Donald J Exp Med Article The administration of penicillin in relatively large but non-toxic doses to dba mice after injection with murine typhus rickettsiae resulted in a marked reduction in mortality, particularly when the initial dosage of rickettsiae was relatively small, approaching the minimal lethal dose. No evidence of secondary bacterial infection was obtained by bacteriological and histological studies, and it seems justifiable to conclude that the greatly increased survival rate in the treated mice was caused by the action of penicillin on typhus rickettsiae. The theoretical and practical implications of the results are discussed. The Rockefeller University Press 1944-04-01 /pmc/articles/PMC2135392/ /pubmed/19871379 Text en Copyright © Copyright, 1944, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Moragues, Vicente
Pinkerton, Henry
Greiff, Donald
THERAPEUTIC EFFECTIVENESS OF PENICILLIN IN EXPERIMENTAL MURINE TYPHUS INFECTION IN dba MICE
title THERAPEUTIC EFFECTIVENESS OF PENICILLIN IN EXPERIMENTAL MURINE TYPHUS INFECTION IN dba MICE
title_full THERAPEUTIC EFFECTIVENESS OF PENICILLIN IN EXPERIMENTAL MURINE TYPHUS INFECTION IN dba MICE
title_fullStr THERAPEUTIC EFFECTIVENESS OF PENICILLIN IN EXPERIMENTAL MURINE TYPHUS INFECTION IN dba MICE
title_full_unstemmed THERAPEUTIC EFFECTIVENESS OF PENICILLIN IN EXPERIMENTAL MURINE TYPHUS INFECTION IN dba MICE
title_short THERAPEUTIC EFFECTIVENESS OF PENICILLIN IN EXPERIMENTAL MURINE TYPHUS INFECTION IN dba MICE
title_sort therapeutic effectiveness of penicillin in experimental murine typhus infection in dba mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135392/
https://www.ncbi.nlm.nih.gov/pubmed/19871379
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AT greiffdonald therapeuticeffectivenessofpenicillininexperimentalmurinetyphusinfectionindbamice

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