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INCREASED RESISTANCE TO VIRAL INFECTION AS A RESULT OF INCREASED FLUID IN TISSUES

Experiments are described in which it is shown that the estrogenic hormone (α-estradiol propionate) increases the amount of extracellular fluid in the skin. Since previous work showed that this hormone increases resistance of rabbits to vaccinia virus, it is suggested that the increased resistance i...

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Detalles Bibliográficos
Autores principales: Taylor, Haywood M., Sprunt, Douglas H.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1943
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135396/
https://www.ncbi.nlm.nih.gov/pubmed/19871316
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author Taylor, Haywood M.
Sprunt, Douglas H.
author_facet Taylor, Haywood M.
Sprunt, Douglas H.
author_sort Taylor, Haywood M.
collection PubMed
description Experiments are described in which it is shown that the estrogenic hormone (α-estradiol propionate) increases the amount of extracellular fluid in the skin. Since previous work showed that this hormone increases resistance of rabbits to vaccinia virus, it is suggested that the increased resistance is the result of increased fluid in the tissues. In further test of this thesis, experiments were performed in which the extracellular fluid in the skin was increased by the intraperitoneal injection of a salt solution known to increase the hydration of the tissues. Under these conditions it was found that the spread of India ink in the skin, as well as susceptibility to viral infection, was decreased in the same magnitude as obtains when the animals are treated with estrogenic hormone. The identity of effects under the two sets of circumstances seems to warrant the conclusion that in both instances the spread of India ink and decreased susceptibility to vaccinia are due to the common factor of increased volume of the extracellular fluid.
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spelling pubmed-21353962008-04-18 INCREASED RESISTANCE TO VIRAL INFECTION AS A RESULT OF INCREASED FLUID IN TISSUES Taylor, Haywood M. Sprunt, Douglas H. J Exp Med Article Experiments are described in which it is shown that the estrogenic hormone (α-estradiol propionate) increases the amount of extracellular fluid in the skin. Since previous work showed that this hormone increases resistance of rabbits to vaccinia virus, it is suggested that the increased resistance is the result of increased fluid in the tissues. In further test of this thesis, experiments were performed in which the extracellular fluid in the skin was increased by the intraperitoneal injection of a salt solution known to increase the hydration of the tissues. Under these conditions it was found that the spread of India ink in the skin, as well as susceptibility to viral infection, was decreased in the same magnitude as obtains when the animals are treated with estrogenic hormone. The identity of effects under the two sets of circumstances seems to warrant the conclusion that in both instances the spread of India ink and decreased susceptibility to vaccinia are due to the common factor of increased volume of the extracellular fluid. The Rockefeller University Press 1943-08-01 /pmc/articles/PMC2135396/ /pubmed/19871316 Text en Copyright © Copyright, 1943, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Taylor, Haywood M.
Sprunt, Douglas H.
INCREASED RESISTANCE TO VIRAL INFECTION AS A RESULT OF INCREASED FLUID IN TISSUES
title INCREASED RESISTANCE TO VIRAL INFECTION AS A RESULT OF INCREASED FLUID IN TISSUES
title_full INCREASED RESISTANCE TO VIRAL INFECTION AS A RESULT OF INCREASED FLUID IN TISSUES
title_fullStr INCREASED RESISTANCE TO VIRAL INFECTION AS A RESULT OF INCREASED FLUID IN TISSUES
title_full_unstemmed INCREASED RESISTANCE TO VIRAL INFECTION AS A RESULT OF INCREASED FLUID IN TISSUES
title_short INCREASED RESISTANCE TO VIRAL INFECTION AS A RESULT OF INCREASED FLUID IN TISSUES
title_sort increased resistance to viral infection as a result of increased fluid in tissues
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135396/
https://www.ncbi.nlm.nih.gov/pubmed/19871316
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