THE STABILITY OF VARIOLA VIRUS PROPAGATED IN EMBRYONATED EGGS

After 24 transfers in embryonated eggs a strain of variola virus (Chinese) was established in the testis of the rabbit and maintained for 11 passages at intervals of 7 days. Residence in the rabbit testis was not accompanied by any significant alteration in the species identity of the virus. A secon...

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Detalles Bibliográficos
Autor principal: Nelson, John B.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1943
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135401/
https://www.ncbi.nlm.nih.gov/pubmed/19871324
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author Nelson, John B.
author_facet Nelson, John B.
author_sort Nelson, John B.
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description After 24 transfers in embryonated eggs a strain of variola virus (Chinese) was established in the testis of the rabbit and maintained for 11 passages at intervals of 7 days. Residence in the rabbit testis was not accompanied by any significant alteration in the species identity of the virus. A second strain of variola virus (Minnesota) was transferred 180 times in embryonated eggs with no apparent change in its behavior. Subsequent attempts, however, to maintain this strain in the rabbit by serial testicular passage were unsuccessful. These observations are discussed in relation to the so called transformation of variola to vaccinia virus by animal passage.
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spelling pubmed-21354012008-04-18 THE STABILITY OF VARIOLA VIRUS PROPAGATED IN EMBRYONATED EGGS Nelson, John B. J Exp Med Article After 24 transfers in embryonated eggs a strain of variola virus (Chinese) was established in the testis of the rabbit and maintained for 11 passages at intervals of 7 days. Residence in the rabbit testis was not accompanied by any significant alteration in the species identity of the virus. A second strain of variola virus (Minnesota) was transferred 180 times in embryonated eggs with no apparent change in its behavior. Subsequent attempts, however, to maintain this strain in the rabbit by serial testicular passage were unsuccessful. These observations are discussed in relation to the so called transformation of variola to vaccinia virus by animal passage. The Rockefeller University Press 1943-10-01 /pmc/articles/PMC2135401/ /pubmed/19871324 Text en Copyright © Copyright, 1943, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Nelson, John B.
THE STABILITY OF VARIOLA VIRUS PROPAGATED IN EMBRYONATED EGGS
title THE STABILITY OF VARIOLA VIRUS PROPAGATED IN EMBRYONATED EGGS
title_full THE STABILITY OF VARIOLA VIRUS PROPAGATED IN EMBRYONATED EGGS
title_fullStr THE STABILITY OF VARIOLA VIRUS PROPAGATED IN EMBRYONATED EGGS
title_full_unstemmed THE STABILITY OF VARIOLA VIRUS PROPAGATED IN EMBRYONATED EGGS
title_short THE STABILITY OF VARIOLA VIRUS PROPAGATED IN EMBRYONATED EGGS
title_sort stability of variola virus propagated in embryonated eggs
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135401/
https://www.ncbi.nlm.nih.gov/pubmed/19871324
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