THE CARDIOTOXIC ACTION OF PREPARATIONS CONTAINING THE OXYGEN-LABILE HEMOLYSIN OF STREPTOCOCCUS PYOGENES : II. INHIBITION OF CARDIOTOXIC EFFECT BY A SUBSTANCE RELEASED FROM THE FROG'S HEART

1. The mechanism of sensitization of the isolated frog' heart to a product of the hemolytic streptococcus has been investigated. The sensitization depends upon the release from the isolated heart of a substance which inhibits the action of the cardiotoxin. The inhibitor is released upon the fir...

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Detalles Bibliográficos
Autores principales: Cantoni, G. L., Bernheimer, Alan W.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1945
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135491/
https://www.ncbi.nlm.nih.gov/pubmed/19871459
Descripción
Sumario:1. The mechanism of sensitization of the isolated frog' heart to a product of the hemolytic streptococcus has been investigated. The sensitization depends upon the release from the isolated heart of a substance which inhibits the action of the cardiotoxin. The inhibitor is released upon the first (sensitizing) administration of cardiotoxin, but not upon the second (contracture-producing) administration. 2. The inhibitor released by the heart neutralizes the lethal factor present in the streptococcal preparation employed. 3. Some of the properties of the inhibitor have been investigated.

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