THE CARDIOTOXIC ACTION OF PREPARATIONS CONTAINING THE OXYGEN-LABILE HEMOLYSIN OF STREPTOCOCCUS PYOGENES : II. INHIBITION OF CARDIOTOXIC EFFECT BY A SUBSTANCE RELEASED FROM THE FROG'S HEART

1. The mechanism of sensitization of the isolated frog' heart to a product of the hemolytic streptococcus has been investigated. The sensitization depends upon the release from the isolated heart of a substance which inhibits the action of the cardiotoxin. The inhibitor is released upon the fir...

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Detalles Bibliográficos
Autores principales: Cantoni, G. L., Bernheimer, Alan W.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1945
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135491/
https://www.ncbi.nlm.nih.gov/pubmed/19871459
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author Cantoni, G. L.
Bernheimer, Alan W.
author_facet Cantoni, G. L.
Bernheimer, Alan W.
author_sort Cantoni, G. L.
collection PubMed
description 1. The mechanism of sensitization of the isolated frog' heart to a product of the hemolytic streptococcus has been investigated. The sensitization depends upon the release from the isolated heart of a substance which inhibits the action of the cardiotoxin. The inhibitor is released upon the first (sensitizing) administration of cardiotoxin, but not upon the second (contracture-producing) administration. 2. The inhibitor released by the heart neutralizes the lethal factor present in the streptococcal preparation employed. 3. Some of the properties of the inhibitor have been investigated.
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spelling pubmed-21354912008-04-18 THE CARDIOTOXIC ACTION OF PREPARATIONS CONTAINING THE OXYGEN-LABILE HEMOLYSIN OF STREPTOCOCCUS PYOGENES : II. INHIBITION OF CARDIOTOXIC EFFECT BY A SUBSTANCE RELEASED FROM THE FROG'S HEART Cantoni, G. L. Bernheimer, Alan W. J Exp Med Article 1. The mechanism of sensitization of the isolated frog' heart to a product of the hemolytic streptococcus has been investigated. The sensitization depends upon the release from the isolated heart of a substance which inhibits the action of the cardiotoxin. The inhibitor is released upon the first (sensitizing) administration of cardiotoxin, but not upon the second (contracture-producing) administration. 2. The inhibitor released by the heart neutralizes the lethal factor present in the streptococcal preparation employed. 3. Some of the properties of the inhibitor have been investigated. The Rockefeller University Press 1945-03-01 /pmc/articles/PMC2135491/ /pubmed/19871459 Text en Copyright © Copyright, 1945, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Cantoni, G. L.
Bernheimer, Alan W.
THE CARDIOTOXIC ACTION OF PREPARATIONS CONTAINING THE OXYGEN-LABILE HEMOLYSIN OF STREPTOCOCCUS PYOGENES : II. INHIBITION OF CARDIOTOXIC EFFECT BY A SUBSTANCE RELEASED FROM THE FROG'S HEART
title THE CARDIOTOXIC ACTION OF PREPARATIONS CONTAINING THE OXYGEN-LABILE HEMOLYSIN OF STREPTOCOCCUS PYOGENES : II. INHIBITION OF CARDIOTOXIC EFFECT BY A SUBSTANCE RELEASED FROM THE FROG'S HEART
title_full THE CARDIOTOXIC ACTION OF PREPARATIONS CONTAINING THE OXYGEN-LABILE HEMOLYSIN OF STREPTOCOCCUS PYOGENES : II. INHIBITION OF CARDIOTOXIC EFFECT BY A SUBSTANCE RELEASED FROM THE FROG'S HEART
title_fullStr THE CARDIOTOXIC ACTION OF PREPARATIONS CONTAINING THE OXYGEN-LABILE HEMOLYSIN OF STREPTOCOCCUS PYOGENES : II. INHIBITION OF CARDIOTOXIC EFFECT BY A SUBSTANCE RELEASED FROM THE FROG'S HEART
title_full_unstemmed THE CARDIOTOXIC ACTION OF PREPARATIONS CONTAINING THE OXYGEN-LABILE HEMOLYSIN OF STREPTOCOCCUS PYOGENES : II. INHIBITION OF CARDIOTOXIC EFFECT BY A SUBSTANCE RELEASED FROM THE FROG'S HEART
title_short THE CARDIOTOXIC ACTION OF PREPARATIONS CONTAINING THE OXYGEN-LABILE HEMOLYSIN OF STREPTOCOCCUS PYOGENES : II. INHIBITION OF CARDIOTOXIC EFFECT BY A SUBSTANCE RELEASED FROM THE FROG'S HEART
title_sort cardiotoxic action of preparations containing the oxygen-labile hemolysin of streptococcus pyogenes : ii. inhibition of cardiotoxic effect by a substance released from the frog's heart
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135491/
https://www.ncbi.nlm.nih.gov/pubmed/19871459
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