THE CARDIOTOXIC ACTION OF PREPARATIONS CONTAINING THE OXYGEN-LABILE HEMOLYSIN OF STREPTOCOCCUS PYOGENES : I. INCREASED SENSITIVITY OF THE ISOLATED FROG'S HEART TO REPEATED APPLICATION OF THE TOXIN

1. A study has been made of the effect on the isolated frog's heart of a preparation derived from the supernatant fluid of cultures of hemolytic streptococcus. 2. The streptococcal preparation was found to induce systolic contracture, the contracture usually developing only after the second of...

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Autores principales: Bernheimer, Alan W., Cantoni, G. L.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1945
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135492/
https://www.ncbi.nlm.nih.gov/pubmed/19871458
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author Bernheimer, Alan W.
Cantoni, G. L.
author_facet Bernheimer, Alan W.
Cantoni, G. L.
author_sort Bernheimer, Alan W.
collection PubMed
description 1. A study has been made of the effect on the isolated frog's heart of a preparation derived from the supernatant fluid of cultures of hemolytic streptococcus. 2. The streptococcal preparation was found to induce systolic contracture, the contracture usually developing only after the second of two administrations of the preparation. It was found that a single application of the streptococcal preparation sensitized the heart to a second application. 3. The properties of the cardiotoxic factor so far as they have been studied were found to be identical with those of the oxygen-labile hemolysin of streptococci. The capacity of normal and of immune sera to neutralize the cardiotoxic action paralleled the antihemolytic potency of the sera.
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spelling pubmed-21354922008-04-18 THE CARDIOTOXIC ACTION OF PREPARATIONS CONTAINING THE OXYGEN-LABILE HEMOLYSIN OF STREPTOCOCCUS PYOGENES : I. INCREASED SENSITIVITY OF THE ISOLATED FROG'S HEART TO REPEATED APPLICATION OF THE TOXIN Bernheimer, Alan W. Cantoni, G. L. J Exp Med Article 1. A study has been made of the effect on the isolated frog's heart of a preparation derived from the supernatant fluid of cultures of hemolytic streptococcus. 2. The streptococcal preparation was found to induce systolic contracture, the contracture usually developing only after the second of two administrations of the preparation. It was found that a single application of the streptococcal preparation sensitized the heart to a second application. 3. The properties of the cardiotoxic factor so far as they have been studied were found to be identical with those of the oxygen-labile hemolysin of streptococci. The capacity of normal and of immune sera to neutralize the cardiotoxic action paralleled the antihemolytic potency of the sera. The Rockefeller University Press 1945-03-01 /pmc/articles/PMC2135492/ /pubmed/19871458 Text en Copyright © Copyright, 1945, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Bernheimer, Alan W.
Cantoni, G. L.
THE CARDIOTOXIC ACTION OF PREPARATIONS CONTAINING THE OXYGEN-LABILE HEMOLYSIN OF STREPTOCOCCUS PYOGENES : I. INCREASED SENSITIVITY OF THE ISOLATED FROG'S HEART TO REPEATED APPLICATION OF THE TOXIN
title THE CARDIOTOXIC ACTION OF PREPARATIONS CONTAINING THE OXYGEN-LABILE HEMOLYSIN OF STREPTOCOCCUS PYOGENES : I. INCREASED SENSITIVITY OF THE ISOLATED FROG'S HEART TO REPEATED APPLICATION OF THE TOXIN
title_full THE CARDIOTOXIC ACTION OF PREPARATIONS CONTAINING THE OXYGEN-LABILE HEMOLYSIN OF STREPTOCOCCUS PYOGENES : I. INCREASED SENSITIVITY OF THE ISOLATED FROG'S HEART TO REPEATED APPLICATION OF THE TOXIN
title_fullStr THE CARDIOTOXIC ACTION OF PREPARATIONS CONTAINING THE OXYGEN-LABILE HEMOLYSIN OF STREPTOCOCCUS PYOGENES : I. INCREASED SENSITIVITY OF THE ISOLATED FROG'S HEART TO REPEATED APPLICATION OF THE TOXIN
title_full_unstemmed THE CARDIOTOXIC ACTION OF PREPARATIONS CONTAINING THE OXYGEN-LABILE HEMOLYSIN OF STREPTOCOCCUS PYOGENES : I. INCREASED SENSITIVITY OF THE ISOLATED FROG'S HEART TO REPEATED APPLICATION OF THE TOXIN
title_short THE CARDIOTOXIC ACTION OF PREPARATIONS CONTAINING THE OXYGEN-LABILE HEMOLYSIN OF STREPTOCOCCUS PYOGENES : I. INCREASED SENSITIVITY OF THE ISOLATED FROG'S HEART TO REPEATED APPLICATION OF THE TOXIN
title_sort cardiotoxic action of preparations containing the oxygen-labile hemolysin of streptococcus pyogenes : i. increased sensitivity of the isolated frog's heart to repeated application of the toxin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135492/
https://www.ncbi.nlm.nih.gov/pubmed/19871458
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