STUDIES ON THE DENATURATION OF ANTIBODY : II. THE EFFECT OF PROTEIN CONCENTRATION ON THE RATE OF DENATURATION OF DIPHTHERIA ANTITOXIN BY UREA

The specific rate of inactivation of antitoxin in urea solutions, as measured by the Römer neutralization test with toxin, has been shown to be independent of the concentration of protein under the conditions studied. The amount of precipitate obtained in the quantitative precipitation test with tox...

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Detalles Bibliográficos
Autor principal: Wright, George G.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1945
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135519/
https://www.ncbi.nlm.nih.gov/pubmed/19871481
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author Wright, George G.
author_facet Wright, George G.
author_sort Wright, George G.
collection PubMed
description The specific rate of inactivation of antitoxin in urea solutions, as measured by the Römer neutralization test with toxin, has been shown to be independent of the concentration of protein under the conditions studied. The amount of precipitate obtained in the quantitative precipitation test with toxin, however, increases greatly with increasing protein concentration during denaturation. The time during which the protein concentration is important in this respect has been shown to be the interval in which the urea is being dialyzed from the solutions. The meaning of the results is discussed.
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spelling pubmed-21355192008-04-18 STUDIES ON THE DENATURATION OF ANTIBODY : II. THE EFFECT OF PROTEIN CONCENTRATION ON THE RATE OF DENATURATION OF DIPHTHERIA ANTITOXIN BY UREA Wright, George G. J Exp Med Article The specific rate of inactivation of antitoxin in urea solutions, as measured by the Römer neutralization test with toxin, has been shown to be independent of the concentration of protein under the conditions studied. The amount of precipitate obtained in the quantitative precipitation test with toxin, however, increases greatly with increasing protein concentration during denaturation. The time during which the protein concentration is important in this respect has been shown to be the interval in which the urea is being dialyzed from the solutions. The meaning of the results is discussed. The Rockefeller University Press 1945-06-01 /pmc/articles/PMC2135519/ /pubmed/19871481 Text en Copyright © Copyright, 1945, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Wright, George G.
STUDIES ON THE DENATURATION OF ANTIBODY : II. THE EFFECT OF PROTEIN CONCENTRATION ON THE RATE OF DENATURATION OF DIPHTHERIA ANTITOXIN BY UREA
title STUDIES ON THE DENATURATION OF ANTIBODY : II. THE EFFECT OF PROTEIN CONCENTRATION ON THE RATE OF DENATURATION OF DIPHTHERIA ANTITOXIN BY UREA
title_full STUDIES ON THE DENATURATION OF ANTIBODY : II. THE EFFECT OF PROTEIN CONCENTRATION ON THE RATE OF DENATURATION OF DIPHTHERIA ANTITOXIN BY UREA
title_fullStr STUDIES ON THE DENATURATION OF ANTIBODY : II. THE EFFECT OF PROTEIN CONCENTRATION ON THE RATE OF DENATURATION OF DIPHTHERIA ANTITOXIN BY UREA
title_full_unstemmed STUDIES ON THE DENATURATION OF ANTIBODY : II. THE EFFECT OF PROTEIN CONCENTRATION ON THE RATE OF DENATURATION OF DIPHTHERIA ANTITOXIN BY UREA
title_short STUDIES ON THE DENATURATION OF ANTIBODY : II. THE EFFECT OF PROTEIN CONCENTRATION ON THE RATE OF DENATURATION OF DIPHTHERIA ANTITOXIN BY UREA
title_sort studies on the denaturation of antibody : ii. the effect of protein concentration on the rate of denaturation of diphtheria antitoxin by urea
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135519/
https://www.ncbi.nlm.nih.gov/pubmed/19871481
work_keys_str_mv AT wrightgeorgeg studiesonthedenaturationofantibodyiitheeffectofproteinconcentrationontherateofdenaturationofdiphtheriaantitoxinbyurea

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