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THE PROTECTIVE ACTION OF TRYPAN RED AGAINST INFECTION BY A NEUROTROPIC VIRUS

Trypan red, when injected intraperitoneally into mice, has been found greatly to lower the incidence of the infection of mice inoculated intraperitoneally with the neurotropic MM virus. The protective action of the dye is overcome if the virus is inoculated in too high concentration. The lowered inc...

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Autores principales: Wood, Harland G., Rusoff, Irving I.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1945
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135559/
https://www.ncbi.nlm.nih.gov/pubmed/19871501
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author Wood, Harland G.
Rusoff, Irving I.
author_facet Wood, Harland G.
Rusoff, Irving I.
author_sort Wood, Harland G.
collection PubMed
description Trypan red, when injected intraperitoneally into mice, has been found greatly to lower the incidence of the infection of mice inoculated intraperitoneally with the neurotropic MM virus. The protective action of the dye is overcome if the virus is inoculated in too high concentration. The lowered incidence of infection was observed in mice inoculated with virus for as long as 29 days after the last dye injection. Of a number of dyes tested, trypan red, brilliant vital red, and Congo red were found effective. In cotton rats inoculated intraperitoneally with MM virus, trypan red was likewise found to lower the incidence of infection. With monkeys and a typical poliomyelitis virus no protection was observed against the virus inoculated intraperitoneally. The latter experiment is considered to have been inadequate for a critical test of the effect of trypan red on poliomyelitis infection. When either the MM virus or Lansing virus were inoculated intracerebrally into mice, the effect of the dye on incidence of infection was small. In the case of the Lansing virus the difference was statistically significant, however. The possible relation of alteration in the permeability of the barrier between the blood and the central nervous system as a cause of the effect of trypan red is discussed.
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spelling pubmed-21355592008-04-18 THE PROTECTIVE ACTION OF TRYPAN RED AGAINST INFECTION BY A NEUROTROPIC VIRUS Wood, Harland G. Rusoff, Irving I. J Exp Med Article Trypan red, when injected intraperitoneally into mice, has been found greatly to lower the incidence of the infection of mice inoculated intraperitoneally with the neurotropic MM virus. The protective action of the dye is overcome if the virus is inoculated in too high concentration. The lowered incidence of infection was observed in mice inoculated with virus for as long as 29 days after the last dye injection. Of a number of dyes tested, trypan red, brilliant vital red, and Congo red were found effective. In cotton rats inoculated intraperitoneally with MM virus, trypan red was likewise found to lower the incidence of infection. With monkeys and a typical poliomyelitis virus no protection was observed against the virus inoculated intraperitoneally. The latter experiment is considered to have been inadequate for a critical test of the effect of trypan red on poliomyelitis infection. When either the MM virus or Lansing virus were inoculated intracerebrally into mice, the effect of the dye on incidence of infection was small. In the case of the Lansing virus the difference was statistically significant, however. The possible relation of alteration in the permeability of the barrier between the blood and the central nervous system as a cause of the effect of trypan red is discussed. The Rockefeller University Press 1945-10-31 /pmc/articles/PMC2135559/ /pubmed/19871501 Text en Copyright © Copyright, 1945, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Wood, Harland G.
Rusoff, Irving I.
THE PROTECTIVE ACTION OF TRYPAN RED AGAINST INFECTION BY A NEUROTROPIC VIRUS
title THE PROTECTIVE ACTION OF TRYPAN RED AGAINST INFECTION BY A NEUROTROPIC VIRUS
title_full THE PROTECTIVE ACTION OF TRYPAN RED AGAINST INFECTION BY A NEUROTROPIC VIRUS
title_fullStr THE PROTECTIVE ACTION OF TRYPAN RED AGAINST INFECTION BY A NEUROTROPIC VIRUS
title_full_unstemmed THE PROTECTIVE ACTION OF TRYPAN RED AGAINST INFECTION BY A NEUROTROPIC VIRUS
title_short THE PROTECTIVE ACTION OF TRYPAN RED AGAINST INFECTION BY A NEUROTROPIC VIRUS
title_sort protective action of trypan red against infection by a neurotropic virus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135559/
https://www.ncbi.nlm.nih.gov/pubmed/19871501
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